Chronic myelogenous leukemia

Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy

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Fig. 1: Detection of BCR–ABL, CBFB rearrangements, and del(9p) by in situ hybridization.
Fig. 2: Evolution of tumor population and clinical response post CAR-T.

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Acknowledgements

The authors thank the patient and family, as well as the MGH nurses, advanced practitioners, research, and support staff. This retrospective analysis was approved by the Dana Farber/Harvard Cancer Center Institutional Review Board.

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VV, MO, PDC, VN, JEF, CH, PCA, KSC, MJF, MKB, AMB, ATF, HH, JM, SM, TAG, and GH designed the research, analyzed results, made the figures, and wrote the paper; MO, PDC, TAG, and VN performed experiments. Vineet Sharma provided technical assistance with figure generation.

Corresponding author

Correspondence to Gabriela S. Hobbs.

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Conflict of interest

VV, KSC, MO, PDC, VN, PCA, MKB, JEF, JM, HH, CH, SM, and AMB, have no interests to disclose. ATF does scientific consulting for Celgene/BMS, Novartis, Agios, Astellas, Pfizer, Takeda, Amgen, Daiichi Sankyo, Kite, Trovagene, Forty-Seven, NewLink Genetics, and Abbvie, and receives research funding from Celgene and Abbvie. MF does scientific consulting for Novartis, Gilead, Celgene, Arcellx and is funded by the NIH K12CA087723. TG receives research support from Janssen and Calico. GH does scientific consulting for Incyte, Agios, Celgene, BMS, and Jazz as well as receives research support from Bayer, Incyte, Merck, Constellation and research grants in the form of NIH K12 CA087723 Paul Calabresi Award, ASH-AMFDP, and Sanchez Ferguson Research Award.

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Venkataraman, V., Casey, K.S., Onozato, M. et al. Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy. Leukemia (2020). https://doi.org/10.1038/s41375-020-0983-x

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