Myelodysplastic syndrome

Which lower risk myelodysplastic syndromes should be treated with allogeneic hematopoietic stem cell transplantation?

Abstract

Indications of allogeneic hematopoietic stem cell transplantation (HSCT) remain controversial in patients with lower risk myelodysplastic syndrome. We review prognostic factors in lower risk MDS, delineating patients with relatively poor risk who may potentially benefit from HSCT during the disease course. Results of HSCT in those patients, and main efforts to decrease non-relapse mortality (NRM) are detailed. Prospective studies are needed to determine more precisely which lower risk MDS patients may benefit from transplantation.

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Fig. 1: Estimation of NRM according to disease risk, comorbidity score, type of donor, and conditioning regimen (published by Carre et al [33]).

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Robin, M., Fenaux, P. Which lower risk myelodysplastic syndromes should be treated with allogeneic hematopoietic stem cell transplantation?. Leukemia (2020). https://doi.org/10.1038/s41375-020-0967-x

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