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A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models

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Fig. 1: Phenotypic and molecular analysis of TLX1-driven zebrafish T-ALL.
Fig. 2: Comparative of gene expression analysis the phf6/hTLX1, hulk, hMYC, otg, and shrek T-ALL models.


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We would like to thank our zebrafish caretaker Karen Vermeulen for all her nurturing work. In addition, we would like to thank following agencies for funding reagents, zebrafish facility costs, and personnel expenses: FWO Vlaanderen (Fund for scientific research Flanders) (post)doctoral grants for SL, SV, and KD, FWO research project GO37918N; GOA: BOF16/GOA/023; BOF: 01J15119; Villa Joep; Kinderkankerfonds; Kom op tegen kanker: Emmanuel van der Schueren grant for LD and SL; Stichting tegen kanker project number: F/2014/373; the computational resources (Stevin Supercomputer Infrastructure) and services used in this work were provided by the VSC (Flemish Supercomputer Center), funded by Ghent University, FWO and the Flemish Government—department EWI. DML is funded by NIH (R01CA211734) and the MGH Research Scholars Program. JKF and his laboratory were supported by the OUHSC Jimmy Everest Section of Pediatric Hematology-Oncology and grants from Hyundai Hope On Wheels, the Oklahoma Center for the Advancement of Science and Technology (HRP-067), and an INBRE pilot project award from the National Institute of General Medical Sciences (P20 GM103447). JKF holds the Children’s Hospital Foundation E.L. and Thelma Gaylord Endowed Chair in Pediatric Hematology-Oncology. Research reported in this publication was supported in part by the National Cancer Institute Cancer Center Support Grant P30CA225520 awarded to the University of Oklahoma Stephenson Cancer Center and used the Molecular Biology Shared Resource. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Correspondence to Kaat Durinck.

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Loontiens, S., Vanhauwaert, S., Depestel, L. et al. A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Leukemia 34, 3398–3403 (2020).

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