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Chronic lymphocytic leukemia

RETRACTED ARTICLE: Prognostic models for chronic lymphocytic leukemia (CLL): a systematic review and meta-analysis

Leukemia volume 35, pages 615–618 (2021)Cite this article

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This article was retracted on 30 November 2022

This article has been updated

The increased availability of well-established biological markers for chronic lymphocytic leukemia (CLL) represents an opportunity to develop accurate prognostic models or algorithms that integrate a combination of markers. Although some prognostic models explicitly aim to support clinical decision making their usefulness in clinical practice remains uncertain due to methodological shortcomings, insufficient reporting, and lack of external validation [1,2,3,4,5]. Therefore, despite plenty of prognostic models published in the literature, very few have been adopted in clinical use.

To increase understanding of this important clinical question, we conducted a systematic review and meta-analysis in accordance with the PRISMA (preferred reporting items for systematic reviews and meta-analyses) which includes all published studies that have developed or validated prognostic CLL models predicting overall survival (OS) (PRISMA Flow Diagram; Supplementary Fig. 1). OS was chosen as endpoint because it is not susceptible to bias of the outcome assessor and has the greatest clinical relevance in CLL.

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Fig. 1: Meta-analysis of the c-statistics.
Fig. 2: Calibration analysis.

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Authors and Affiliations

  1. Department Hematology–Oncology, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy

    Stefano Molica

  2. Biostatistic Unit, IRCCS Regina Elena, Roma, Italy

    Diana Giannarelli

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  1. Stefano Molica
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  2. Diana Giannarelli
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Contributions

SM designed the study, selected and evaluated studies, performed data extraction, evaluated and interpreted results, and wrote the paper; DG selected and evaluated studies, performed data extraction, performed statistical analyses, and evaluated results.

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Correspondence to Stefano Molica.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1038/s41375-022-01771-2

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Molica, S., Giannarelli, D. RETRACTED ARTICLE: Prognostic models for chronic lymphocytic leukemia (CLL): a systematic review and meta-analysis. Leukemia 35, 615–618 (2021). https://doi.org/10.1038/s41375-020-0924-8

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