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Acute myeloid leukemia

Benzene induces rapid leukemic transformation after prolonged hematotoxicity in a murine model

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Fig. 1: Benzene induces rapid leukemic transformation after prolonged hematotoxicity in transplant Mll–Af9 murine model.
Fig. 2: Transcriptome and genome analysis of AML cells among benzene group and air control group.


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This work was supported by the Beijing Natural Science Foundation (No. 7182118), the National Natural Science Foundation of China (No. 81641009), the Social Development Project of Jiangsu Province (No. BE2017659), and the Youth Innovation Promotion Association of the Chinese Academy of Sciences (to C.A.L.). We acknowledge Bing Liu at Academy of Military Medical Sciences for kindly providing the male B6.SJL mouse strain. We are grateful to Nan Lian at West China School of Public Health for technical assistance.

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JZ and BW performed experiments; CX, QW, HG, and AC designed experiments; JZ, PS, and JS analyzed data; YL, FH, and XC established techniques of flow cytometry; SC helped to monitor the concentration of benzene; QWang, CX, JZ, and PS wrote the manuscript. All authors approved and take shared responsibility for the final submitted version of the manuscript.

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Correspondence to Caihong Xing or Qian-fei Wang.

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Zhao, J., Sui, P., Wu, B. et al. Benzene induces rapid leukemic transformation after prolonged hematotoxicity in a murine model. Leukemia 35, 595–600 (2021).

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