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Acute myeloid leukemia

The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia

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Fig. 1: Cell surface characterization of human acute leukemia cells with anti-CD33∆E2 antibodies.
Fig. 2: Whole cell characterization of human acute leukemia cells with anti-CD33∆E2 antibodies.


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We thank Dr. Derek L. Stirewalt and Era Pogosova-Agadjanyan for provision of primary human AML specimens from the Fred Hutchinson Cancer Research Center/University of Washington Hematopoietic Diseases Repository. Research reported in this publication was supported by the Leukemia & Lymphoma Society (Translational Research Program, grant 6489–16) and the National Institutes of Health/National Cancer Institute (NIH/NCI) (R21-CA234203, P30-CA015704, and P50-CA100632 [MD Anderson Cancer Center Leukemia SPORE]). C.D.G. is supported by a fellowship training grant from the NIH/National Heart, Lung, and Blood Institute (NHLBI; T32-HL007093), an institutional K12 grant from the NIH/NCI (K12-CA076930) an American Society of Clinical Oncology/Conquer Cancer Foundation Young Investigator Award and an Alex’s Lemonade Stand Young Investigator Grant.

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Correspondence to Roland B. Walter.

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Conflict of interest

HPK is a consultant to and has ownership interests with Rocket Pharma and Homology Medicines and is a consultant to CSL Behring and Magenta Therapeutics. RBW received laboratory research grants and/or clinical trial support from Agios, Amgen, Aptevo Therapeutics, Arog, BioLineRx, Jazz, Pfizer, Seattle Genetics, and Selvita; has ownership interests with Amphivena Therapeutics; and is (or has been) a consultant to Agios, Amphivena Therapeutics, Astellas, BiVictrix, Boehringer Ingelheim, Covagen, Emergent Biosolutions/Aptevo Therapeutics, Jazz, Kite, Pfizer, and Seattle Genetics. The other authors declare no competing financial interests.

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Godwin, C.D., Laszlo, G.S., Wood, B.L. et al. The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia. Leukemia 34, 2479–2483 (2020).

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