Acute myeloid leukemia

Biomarkers for RBM39 degradation in acute myeloid leukemia

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Fig. 1: Indisulam activity and assay development for RBM39 degradation detection in patient AML.
Fig. 2: Indisulam induces splicing alterations in patient AML specimens and development of a RT-PCR assay for splicing alteration detection.

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Acknowledgements

We thank members of the Nijhawan lab for helpful advice and discussions. DH was supported by a training award from the American Society of Hematology. DN is supported by Welch Foundation I-1879, NIH R37CA226771, and NIH RO1CA217333. This work was supported in part by funds from Peloton Therapeutics, now a wholly owned subsidiary of Merck, and a grant from the Simmons Cancer Center at UT Southwestern.

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DH participated in the design, executed all of the experiments, and wrote the paper. MG optimized the FACS based assay for RBM39 degradation. JK analyzed RNA sequencing and generated list of splicing alterations. YX is a supervisor for JK, DN conceived the study, designed the experiments, and wrote the paper.

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Correspondence to Deepak Nijhawan.

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DN is a consultant for Peloton Therapeutics, now a wholly owned subsidiary of Merck. The other authors declare no conflict of interest.

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Hsiehchen, D., Goralski, M., Kim, J. et al. Biomarkers for RBM39 degradation in acute myeloid leukemia. Leukemia 34, 1924–1928 (2020). https://doi.org/10.1038/s41375-020-0729-9

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