Acute lymphoblastic leukemia

Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model

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Fig. 1: Cell proliferation and gene expression of Ba/F3 cells induced by NCOR1-LYN.
Fig. 2: Effects of dasatinib and rapamycin on NCOR1-LYN.


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This study was supported by grants-in-aid for scientific research from the Japanese Ministry of Education, Culture, Sports, Science and Technology (17K10124 and 17K16277) and by Grant-in-Aid for Practical Research for Innovative Cancer Control (16ck0106066h0003, 17ck0106253h0001, 18ck0106253h0002, and 19ck0106253h0003).

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T.T. and T.I. designed studies and wrote the manuscript; T.T., T.I., A.M., E.S., M.Y., K.S., and N.K. performed genetic and in vitro functional studies; K.T., I.K., T.M., and M.M. performed in vivo studies using patient-derived xenograft model; K.H., S.A., T.N., J.T., and H.H. supervised research and participated in editing manuscript.

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Correspondence to Toshihiko Imamura.

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Tomii, T., Imamura, T., Tanaka, K. et al. Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model. Leukemia (2020).

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