Multiple myeloma gammopathies

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

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Fig. 1: IRF4 loss results in cell cycle inhibition and death of MM cells.
Fig. 2: IRF4 maintains MM survival through the repression of BMF alone or in combination with BCL2L11.

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Acknowledgements

We acknowledge the help of the Walter and Eliza Hall Institute and Flow Cytometry Core Facilities. We also thank Daniel H.D. Gray for helpful discussions. This work was supported by grants from the National Health and Medical Research Council (Project grants 1143105 (MJH), 1128609 (WS); Ideas grant 1184523 (SLN and SNW); Program grant 1113133 (DCSH)), the Leukemia & Lymphoma Society-Snowdome Foundation-Leukaemia Foundation (LLS-SF-LF; 6592-20) Translational Research Program (TRP) (SLN and SNW), the Leukemia and Lymphoma Society SCOR grant 7015–18 (DCSH and MJH), and the Cancer Council Victoria Grant-in-Aid Project grants 1102662 (SLN) and 1161400 (LAO’R). This work was also supported by fellowships awarded to SLN (NHMRC; 1155342), DCSH (NHMRC; 1156024), MJH (NHMRC; 1156095), SNW (Walter and Eliza Hall Trust Centenary Fellowship), PLF (Cancer Council of Victoria Postdoctoral Research Fellowship), MSYL (NHMRC/RACP CRB Blackburn scholarship; 1075151), WS (Walter and Eliza Hall Institute Centenary Fellowship sponsored by Commonwealth Serum Laboratories Limited), and YY (China Scholarship Council).

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Correspondence to Stephen L. Nutt or Simon N. Willis.

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Fedele, P.L., Liao, Y., Gong, Jn. et al. The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival. Leukemia (2020). https://doi.org/10.1038/s41375-020-01078-0

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