Stem cell biology

DUSP16 is a regulator of human hematopoietic stem and progenitor cells and promotes their expansion ex vivo

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Fig. 1: DUSP16 overexpression enhanced ex vivo expansion of functional human CB HSC/HPC.
Fig. 2: HDACis upregulate DUSP16 expression through inhibition of HDAC1/HDAC3, and functionally mimic DUSP16 overexpression.

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Acknowledgements

These studies were supported by US Public Health Service grants R35 HL139599, R01 DK109188, and U54 DK106846 from the National Institute of Health to HEB. The in vivo Therapeutics Core and the Flow Cytometry Facility of the Indiana University School of Medicine, funded in part by U54 DK106846, for assistance.

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XW and HEB conceived the project and designed the experiments. XW performed the experiments and analyzed the data. XW and HEB wrote and edited the paper.

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Correspondence to Hal E. Broxmeyer.

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Wang, X., Broxmeyer, H.E. DUSP16 is a regulator of human hematopoietic stem and progenitor cells and promotes their expansion ex vivo. Leukemia (2020). https://doi.org/10.1038/s41375-020-01064-6

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