Acute lymphoblastic leukemia

Therapy-related B-cell acute lymphoblastic leukemia in adults has unique genetic profile with frequent loss of TP53 and inferior outcome

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Fig. 1: Overall survival and comparison of frequencies of genetic abnormalities of prognostic significance.
Fig. 2: Distribution of mutations identified in t-B-ALL and de novo B-ALL.

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Acknowledgements

The authors would like to thank the staff of the cytogenetics and molecular diagnostics laboratories for their technical expertise.

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MS undertook concept and design; LBS, JG, Y-HC, OEO, KMM, MB, SND, JKA, FW provided study materials; MS and LBS collected and assembled data; MS, LBS, JG, and MK undertook data analysis and clinical interpretation; MS, LBS, and JG wrote the manuscript; LJ and XL reviewed the manuscript and provided constructive critics, and MS edited the article and provided final approval.

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Correspondence to Madina Sukhanova.

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Barnea Slonim, L., Gao, J., Burkart, M. et al. Therapy-related B-cell acute lymphoblastic leukemia in adults has unique genetic profile with frequent loss of TP53 and inferior outcome. Leukemia (2020). https://doi.org/10.1038/s41375-020-01061-9

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