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Acute lymphoblastic leukemia

An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance

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Fig. 1: KrasLSL-G12D/+.Mb1Cre/+ mice develop T-ALL/T-LLy.
Fig. 2: KrasLSL-G12D/+.Mb1Cre/+ T-ALL/T-LLy has a short latency, causes disease in secondary recipients, and blasts are sensitive to standard chemotherapy agents.

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Acknowledgements

This work was supported by an American Society of Hematology Scholar Award (JJJ); grant RP170074 from the Cancer Prevention and Research Institute of Texas (KRR); funding from the Lynch family (KRR); and by the National Cancer Institute, National Institutes of Health (R01 CA207086 to HDL). Flow cytometry assays were performed at the Research Flow Cytometry Core Facility of Texas Children’s Cancer and Hematology Centers with the support from the Cytometry and Cell Sorting Core at Baylor College of Medicine with funding from the CPRIT Core Facility Support Award (CPRIT-RP180672), the NIH (CA125123 and RR024574), and the assistance of Joel M. Sederstrom. Flow assistance was also generously provided by Amos Gaikwad and Tatiana Goltsova. Histology was performed by the BCM Center for Comparative Medicine Comparative Pathology Laboratory with the assistance of Brian Simons. Microscope assistance was generously provided by Debananda Pati and Nenggang Zhang.

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Correspondence to Jacob J. Junco.

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Junco, J.J., Chen, T., Rashid, R. et al. An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance. Leukemia 35, 1777–1781 (2021). https://doi.org/10.1038/s41375-020-01036-w

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