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Multiple myeloma, gammopathies

RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma

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Fig. 1: RFWD2 is a high-risk gene in multiple myeloma.
Fig. 2: RFWD2 promotes MM cellular proliferation and drug-resistance by regulating P27 degradation.


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This work was supported by National Key Research and Development Program-precision medicine sub-program 2016YFC0905900 (to YY); National Natural Science Foundation of China 81970196 (to CG), 81670200 (to YY); The Priority Academic Program Development of Jiangsu Higher Education Institutions for Chinese Medicine.

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Correspondence to Ye Yang.

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Gu, C., Lu, T., Wang, W. et al. RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma. Leukemia 35, 1803–1807 (2021).

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