In search of genetic factors predisposing to familial hairy cell leukemia (HCL): exome-sequencing of four multiplex HCL pedigrees

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Fig. 1: Pedigree diagrams of four multiplex HCL families.
Fig. 2: Caspase-9 and caspase-3/7 activities in staurosporine-treated CRISPR-unedited HCT116 cells and in HCT116 cells carrying caspase-9 p.H237P and p.R192C substitutions.


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This project was supported by the Division of Cancer Epidemiology and Genetics of the National Cancer Institute, Rockville, MD. This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. This work utilized the computational resources of the NIH High Performance Computing Biowulf cluster. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The Vancouver Lymphoid Cancer Families Study is supported by the Canadian Institutes for Health Research, MOP-130311, and the BC Cancer Foundation. The Vancouver NHL case-control study was supported by the Canadian Cancer Society through the National Cancer Institute of Canada, and the Canadian Institutes of Health Research. The authors thank Joseph M. Connors, MD for his help in initiating the Vancouver Lymphoid Cancer Families Study and referral of one of the families with two affected individuals. The authors would like to thank Katharine Beebe, MPH, Westat, Inc., Rockville, MD, for her help with Fig. 1 preparation.

NCI DCEG Cancer Genomics Research Laboratory

Belynda D. Hicks14, Amy H. Hutchinson14, Michelle Manning14, Aurelie Vogt14, Kristine Jones14, Russell Williams14, Kedest Teshome14, Herb Higson14, Joseph Boland14, Sara Bass14, Bin Zhu14, Wen Luo14, Mingyi Wang14, Dongjing Wu14

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  1. Members of the NCI DCEG Cancer Genomics Research Laboratory are listed below Acknowledgements.

    • Deceased: Henry T. Lynch

      • Henry T. Lynch


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    Correspondence to Douglas R. Stewart.

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    Members of the NCI DCEG Cancer Genomics Research Laboratory are listed below Acknowledgements.

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    Pemov, A., Pathak, A., Jones, S.J. et al. In search of genetic factors predisposing to familial hairy cell leukemia (HCL): exome-sequencing of four multiplex HCL pedigrees. Leukemia (2020). https://doi.org/10.1038/s41375-019-0702-7

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