Fig. 2: CD93 expression can isolate a functional stem cell population in CML. | Leukemia

Fig. 2: CD93 expression can isolate a functional stem cell population in CML.

From: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy

Fig. 2

a Analysis of the microarray, GSE47927, demonstrated a significant fold change between CP-CML LSCs and normal HSCs in genes for cell surface proteins. The table represents the most statistically significant cell surface marker genes identified. b RNA from 30 BM and PB CP-CML samples was utilized to validate the gene expression of CD93. MNC and CD34+-selected (n = 30) samples were compared with normal BM (n = 5). c CD93 protein expression was assessed by flow cytometry in linCD34+CD38CD90+ populations between CML (peripheral blood [n = 22] and BM [n = 9]) and normal BM (n = 7). A statistically significant increase in percentage of CD93+ cells in CML was determined using an unpaired Student’s t test (p < 0.0001). MNC; mononuclear cells, PB; peripheral blood, BM; bone marrow.

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