Smoldering multiple myeloma (SMM) always precedes MM [1, 2]. However only 50% of patients will progress at 5 years and 66% at 10 years [3]. Therefore, defining high-risk SMM represents a clinically fundamental challenge in order to help treatment decision. Many different scoring systems have been developed to predict patients’ outcome [4]. The most broadly used is the Mayo Clinic model that combines M-protein, the percentage of bone marrow plasma cells (BMPC%), and the ratio of involved to uninvolved serum-free light chains (FLCr) [3]. The IMWG recently updated this model and defined new cutoff, namely 2 g/dL for M-protein, 20% for BMPC%, and 20 for the FLCr to categorize patients into three risk groups [5]. While this stratification model is essential for clinical trials it does not capture the molecular characteristics of the tumor cells and the role of the microenvironment, which are potentially crucial factors of progression in SMM.
In this issue, Drs Misund and Keane et al. report the role of MYC translocations in SMM progression (citation of the paper). They used a cohort of 23 MGUS samples, 90 SMM, and 612 newly diagnosed MM samples from the CoMMpass study. None of the MGUS samples had a MYC translocation but it was the case for 24 and 42% of SMM and MM samples, respectively. The time to progression was shorter in patients with SMM harboring an immunoglobulin (Ig)-MYC translocation, even after adjusting for the Mayo Clinic criteria. In contrast, non-Ig-MYC translocations did not correlate to shorter time to progression. Of note, DIS3 mutations were also associated with a higher risk of progression to MM in this cohort.
These data reinforce the fact that MYC translocation is one of the main secondary events in MM oncogenesis. Previous reports identified lower frequency of MYC translocations in newly diagnosed settings (18 and 23%) [6, 7], compared with 42% in the present study. The type of algorithm used to call translocations can explain those differences, as well as the depth of sequencing and the size of the bait set covering the MYC locus in some case. In all analyses, one third of those MYC translocations involved an Ig partner (IGH, IGK, and IGL) and two third a non-Ig partner. Most recurrent of the latter partners are FAM46C, FOXO3, BMP6, or TXNDC5, which are located at superenhancers sites in MM cells, resulting in MYC upregulation.
Interestingly, the authors observe different prognostic values of Ig-MYC vs. non-Ig-MYC translocations; only the first one being associated with adverse outcomes. It was recently reported that IgL-MYC translocations are a marker of poor prognosis in MM [7]. It has been suggested that IgL translocations induce IMiDs resistance by hijacking IKZF1. However the fact that Ig-MYC translocations are associated with a higher risk of progression from SMM to MM indicate an intrinsic high-risk property of those translocations, independently of any treatment. We can hypothesize that the mechanism underlying these translocations or simply the power of the Ig superenhancers can explain this phenotype.
While the present study might be limited by the number of SMM samples it is also a first step toward the molecular classification of SMM, in order to refine the risk stratification of those patients and help treatment decision. Another layer of understanding that future studies will probably elucidate is the role of the immune microenvironment and how it participates to the risk of progression in patients with SMM.
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Manier, S. On the road to molecular prognostication in SMM. Leukemia 34, 331–332 (2020). https://doi.org/10.1038/s41375-019-0627-1
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DOI: https://doi.org/10.1038/s41375-019-0627-1