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Chronic lymphocytic leukemia

Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia

Leukemia volume 34, pages 919–923 (2020)Cite this article

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Chronic lymphocytic leukemia (CLL), the most frequently occurring leukemia in western countries, is a heterogeneous disease and characterized by the accumulation of monoclonal B lymphocytes in blood, bone marrow, and lymphoid tissues [1]. Although diagnosis and therapy have been developing, several high-risk features for CLL patients have been identified [2]. Immunoglobulin heavy-chain variable region (IGHV) has been confirmed as a valuable independent prognostic factor [3]. However, it is of vital importance to explore alternative markers because of limitation of the detection of IGHV mutation in routine laboratory diagnosis process.

Recently, accumulating evidence reveals that non-coding RNAs including circRNAs may exert vital biological functions and can be used as new biomarkers for diagnosis as well as provide promising therapeutic approaches for various solid tumors [4, 5] and leukemias [6, 7]. CircRNAs which are characterized by covalently closed continuous loops without 5′ to 3′ polarity and polyadenylated tail were proved to function as competing endogenous RNAs to interact with microRNAs (miRNAs) and regulate targeted genes expression [8, 9]. However, little is known about the roles of circRNAs in CLL.

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Acknowledgements

This study was supported by National Natural Science Foundation of China (Grant nos. 81700155, 81370657, 81600130, 81770166, 81720108002, 81700114, and 81600078), Jiangsu Province’s Medical Elite Programme (ZDRCA2016022), Jiangsu Provincial Special Program of Medical Science (BE2017751), and National Science and Technology Major Project (2018ZX09734007).

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  1. These authors contributed equally: Zijuan Wu, Handong Sun, Wenjie Liu

Authors and Affiliations

  1. Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China

    Zijuan Wu, Wenjie Liu, Huayuan Zhu, Jianxin Fu, Lei Fan, Li Wang, Wei Xu, Jianyong Li & Hui Jin

  2. Key Laboratory of Hematology of Nanjing Medical University, 210029, Nanjing, China

    Zijuan Wu, Wenjie Liu, Huayuan Zhu, Jianxin Fu, Lei Fan, Li Wang, Wei Xu, Jianyong Li & Hui Jin

  3. Collaborative Innovation Center for Cancer Personalized Medicine, 210029, Nanjing, China

    Zijuan Wu, Wenjie Liu, Huayuan Zhu, Jianxin Fu, Lei Fan, Li Wang, Wei Xu, Jianyong Li & Hui Jin

  4. Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China

    Handong Sun & Chuang Yang

  5. Department of Hematology, Qilu hospital, Shandong University, 250012, Jinan, China

    Yanfeng Liu

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  1. Zijuan Wu
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Correspondence to Jianyong Li or Hui Jin.

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Wu, Z., Sun, H., Liu, W. et al. Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia. Leukemia 34, 919–923 (2020). https://doi.org/10.1038/s41375-019-0594-6

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