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Cornelissen JJ, Gratwohl A, Schlenk RF, Sierra J, Bornhäuser M, Juliusson G, et al. The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nat Rev Clin Oncol. 2012;9:579–90.
Gratwohl A, Stern M, Brand R, Apperley J, Baldomero H, De Witte T, et al. Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis. Cancer. 2009;115:4715–26.
Döhner H, Estey E, Grimwade D, Amadori A, Applebaum FR, Büchner T, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129:424–47.
Freeman SD, Hills RK, Virgo P, Khan N, Couzens S, Dillon R, et al. Measurable residual disease at induction redefines partial response in acute myeloid leukemia and stratifies outcomes in patients at standard risk without NPM1 mutations. J Clin Oncol. 2018;36:1486–97.
Ivey A, Hills RK, Simpson MA, Jovanovic JV, Gilkes A, Grech A, et al. Assessment of minimal residual disease in standard-risk AML. N Engl J Med. 2016;374:422–33.
Araki D, Wood BL, Othus M, Radich JP, Halpern AB, Zhou Y, et al. Allogeneic hematopoietic cell transplantation for acute myeloid leukemia: Time to move toward a minimal residual disease-based definition of complete remission? J Clin Oncol. 2016;34:329–36.
Thol F, Gabdoulline R, Liebich A, Klement P, Schiller J, Kandziora C, et al. Measurable residual disease (MRD) monitoring by NGS before allogeneic hematopoietic cell transplantation in AML. Blood. 2018;132:1703–13.
Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–405.
Medeiros BC. Interpretation of clinical endpoints in trials of acute myeloid leukemia. Leuk Res. 2018;68:32–39.
We thank M. Robinson for thoughtful discussion and formatting support. We also acknowledge the work of Sandra Loaiza, head of operations at the John Goldman Stem Cell Facility and David Slade, data manager at Imperial College Healthcare NHS Trust. AJI is supported by a National Institute for Health Research (NIHR) Clinical Lectureship, and AJI and JFA acknowledges support from the NIHR and Imperial Biomedical Research Centre (BRC).
AJI, JP and RS conceived, designed, performed the research and wrote the manuscript. PW, SL, FF and DB collected and collated data, and AJI and RS performed statistical analysis. PCM, ENM and EYF performed MRD analysis. RP, DM, EO and JFA provided guidance on the research strategy. All authors reviewed and edited the manuscript.
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The authors declare that they have no conflict of interest.
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Innes, A.J., Woolley, P., Szydlo, R.M. et al. Complete remission with incomplete count recovery (CRi) prior to allogeneic HCT for acute myeloid leukaemia is associated with a high non-relapse mortality. Leukemia 34, 667–670 (2020). https://doi.org/10.1038/s41375-019-0572-z