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Multiple myeloma gammopathies

Carfilzomib-induced reticulocytosis in patients with multiple myeloma is caused by impaired terminal erythroid maturation


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This study was supported in part by the UZ Leuven Janssen Hematology Fund and “the Luc Fraiture” Fund. We would like to acknowledge Dr Christa Maes for providing the osteoblastic cell lines and Mrs Annouschka Laenen (L-Biostat and Leuven Cancer Institute, KU Leuven, Belgium) for statistical support, Dr Francis Impens (Proteomics Expertise Center, Flemish Institute of Biotechnology, Ghent, Belgium) for processing and analyzing the LC-MS/MS data and Somersault 18:24 (Diest, Belgium) for their assistance in constructing Fig. 2c.

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NK, KDK, CV and MD designed the research. NK and EH performed the research. NK obtained patient samples. DP performed bioinformatics analyses. NK wrote the manuscript. KDK, CV and MD critically reviewed the manuscript.

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Correspondence to Nicolas G. Kint.

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NK: travel support from Celgene, Amgen and Takeda, MD: speaker’s honoraria from Amgen, Celgene, Janssen, Takeda. Other authors declare that they have no conflict of interest.

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Kint, N.G., Heylen, E., Pepe, D. et al. Carfilzomib-induced reticulocytosis in patients with multiple myeloma is caused by impaired terminal erythroid maturation. Leukemia 34, 651–655 (2020).

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