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This work was supported by NIH grants K08HL106576 (Oh) and T32HL007088 (Fowles). This work was also supported by a grant from the Longer Life Foundation (Oh). Additional support was provided by the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448 from the National Center for Advancing Translational Sciences of NIH. Support for patient sample collection and processing was provided by NIH grant P01CA101937. Exome sequencing was performed at the McDonnell Genome Institute. Technical support was provided by the Alvin J. Siteman Cancer Center Tissue Procurement Core Facility, Flow Cytometry Core, and Immunomonitoring Laboratory, which are supported by NCI Cancer Center Support Grant P30CA91842. The Immunomonitoring Laboratory is also supported by the Bursky Center for Human Immunology and Immunotherapy Programs. The authors thank D. Bender for assistance with multiplex cytokine measurement and C. Miller for assistance with sequencing analysis.