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Chronic lymphocytic leukemia

Dichotomous Toll-like receptor responses in chronic lymphocytic leukemia patients under ibrutinib treatment

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This work was supported in part by the framework of action “IKY Fellowships of excellence for postgraduate studies in Greece - SIEMENS program”; GCH-CLL project funded by ERA-NET TRANSCAN-2 Joint Transnational Call for Proposals 2014 (JTC 2014) and project #179 NOVEL funded by ERA-NET TRANSCAN-2 JTC 2016, by the European Commission/DG Research and Innovation; ODYSSEUS Programme, implemented under the “Action for the Strategic Development on the Research and Technological Sector”, funded by the Operational Programme “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014–2020) and co-financed by Greece and the European Union (European Regional Development Fund); AIRC Investigator grants #20246 and #16777, and Special Program AIRC 5 per mille #21198, Associazione Italiana per la Ricerca sul Cancro AIRC, Milano, Italy; Progetti di Rilevante Interesse Nazionale (PRIN) 2015ZMRFEA, MIUR, Roma, Italy. Maria Gounari and Theodoros Moysiadis are recipients of Marie Sklodowska-Curie individual fellowships (Grant Agreement Numbers: 796491 and 702714, respectively), funded by the European Union’s Horizon 2020 research and innovation programme. Kostas Stamatopoulos and Paolo Ghia received urestricted research funding to this project by Janssen Pharmaceuticals.

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MG and SN designed the research, performed the study, and wrote the manuscript; MG, MGV, KK, NP, AA, EF, PR, and AN assisted in experiments; TM performed statistical analysis; LS, AX, MC, AT, and NS provided patient samples and clinical information; MM, KS, and PG designed and supervised the research and wrote the manuscript.

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Correspondence to Kostas Stamatopoulos.

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Conflict of interest

KS received honoraria from AbbVie, Gilead Science, Janssen and reseach funding from AbbVie, Gilead, Janssen. PG received honoraria from AbbVie, Acerta, BeiGene, Gilead, Janssen, Sunesis and reseach funding from AbbVie, Gilead, Janssen, Novartis. The remaining authors declare that they have no conflict of interest.

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Gounari, M., Ntoufa, S., Gerousi, M. et al. Dichotomous Toll-like receptor responses in chronic lymphocytic leukemia patients under ibrutinib treatment. Leukemia 33, 1030–1051 (2019).

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