Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Acute myeloid leukemia

Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1


  1. Hahn CN, Chong CE, Carmichael CL, Wilkins EJ, Brautigan PJ, Li XC, et al. Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat Genet. 2011;43:1012–7.

    Article  CAS  Google Scholar 

  2. Smith ML, Cavenagh JD, Lister TA, Fitzgibbon J. Mutation of CEBPA in familial acute myeloid leukemia. N Engl J Med. 2014;351:2403–7.

    Article  Google Scholar 

  3. Hemminki K, Jiang Y. Familial myeloid leukemias from the Swedish Family-Cancer Database. Leuk Res. 2002;26:611–3.

    Article  Google Scholar 

  4. Goldin LR, Kristinsson SY, Liang XS, Derolf AR, Landgren O, Björkholm M. Familial aggregation of acute myeloid leukemia and myelodysplastic syndromes. J Clin Oncol. 2012;30:179–83.

    Article  Google Scholar 

  5. Lv H, Zhang M, Shang Z, Li J, Zhang S, Lian D, et al. Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. Oncotarget. 2017;8:7891–9.

    PubMed  Google Scholar 

  6. Knight JA, Skol AD, Shinde A, Hastings D, Walgren RA, Shao J, et al. Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility. Blood. 2009;113:5575–82.

    Article  CAS  Google Scholar 

  7. Di Bernardo MC, Crowther-Swanepoel D, Broderick P, Webb E, Sellick G, Wild R, et al. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat Genet. 2008;40:1204–10.

    Article  Google Scholar 

  8. Kim DH, Lee ST, Won HH, Kim S, Kim MJ, Kim HJ, et al. A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. Blood. 2011;117:6906–11.

    Article  CAS  Google Scholar 

  9. Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, et al. Loci on 7p122, 10q212 and 14q112 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet. 2009;41:1006–10.

    Article  CAS  Google Scholar 

  10. Loeffler M, Engel C, Ahnert P, Alfermann D, Arelin K, Baber R, et al. The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health. 2015;15:691.

    Article  Google Scholar 

  11. Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, et al. Genomics. 2000;64:44–50.

    Article  CAS  Google Scholar 

  12. Rahman S, Sowa ME, Ottinger M, Smith JA, Shi Y, Harper JW, et al. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol. 2011;31:2641–52.

    Article  CAS  Google Scholar 

  13. Roe JS, Vakoc CR. The essential transcriptional function of BRD4 in acute myeloid leukemia. Cold Spring Harb Symp Quant Biol. 2016;81:61–66.

    Article  Google Scholar 

  14. Alpsoy A, Dykhuizen EC. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem. 2018;11:3892–903.

    Article  Google Scholar 

  15. Maharry SE, Walker CJ, Liyanarachchi S, Mehta S, Patel M, Bainazar MA, et al. Dissection of the major hematopoietic quantitative trait locus in chromosome 6q23.3 identifies miR-3662 as a player in hematopoiesis and acute myeloid leukemia. Cancer Discov. 2016;6:1036–51.

    Article  CAS  Google Scholar 

Download references


We would like to acknowledge: the patients who consented to provide material for this study; Jan Lockman and Barbara Fersch for administrative help; Donna Bucci and Wacharaphon Vongchucherd of The Alliance NCTN Biorepository and Biospecimen Resource for sample processing and storage services; the Ohio Supercomputer Center for computational resources; and Lisa J. Sterling of The Ohio State University Comprehensive Cancer Center for data management. This work was supported in part by National Institutes of Health National Cancer Institute grants CA180821 and CA180882 (to the Alliance for Clinical Trials in Oncology), CA196171, CA077658, CA180850, CA180861, CA140158, CA016058, a Pelotonia idea grant, and the Leukemia Clinical Research Foundation.

Author contributions

CJW, CCO, LKG, SL, DN, A-KE, MS, PB, MB, SS, AdlC, and CDB designed the study; MS, PB, MB, AJC, JEK, BLP, ESW, DWN, RMS, JCB, SS, AdlC, and CDB recruited subjects and handled biological samples; CJW, CCO, LKG, and BG performed genotyping; CJW, SL, DN, A-KE, JK, KM, SS, AdlC, and CDB wrote and revised the manuscript.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Clara D. Bloomfield.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Walker, C.J., Oakes, C.C., Genutis, L.K. et al. Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA. Leukemia 33, 771–775 (2019).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links