COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia

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This research was funded in part through a sponsored research agreement from Covagen (to RBW). RBW is a Leukemia and Lymphoma Society Scholar in Clinical Research.

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Correspondence to Simon Brack or Roland B. Walter.

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Conflict of interest

KK, VB, RS, JD, RS, DS, EK, AZ, IA-T, UvdB, SK-F, FD, WL, CA, SW, LD, JB, and SB are employees of Covagen AG. DS and RWH are employees of Janssen R&D. RBW received laboratory research grants and/or clinical trial support from Actinium Pharmaceuticals, Inc., Amgen Inc., Amphivena Therapeutics, Inc., Aptevo Therapeutics, Inc., Covagen AG, and Seattle Genetics, Inc.; has ownership interests with Amphivena Therapeutics, Inc.; and is (or has been) a consultant to Amphivena Therapeutics, Inc., Boehringer Ingelheim Pharma GmbH & Co. KG, Covagen AG, Emergent Biosolutions, Inc. (now Aptevo Therapeutics, Inc.), Pfizer, Inc., and Seattle Genetics, Inc. GSL and CJG declare that they have no conflict of interest.

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Klupsch, K., Baeriswyl, V., Scholz, R. et al. COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia. Leukemia 33, 805–808 (2019).

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