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Stem cell transplantation

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells

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Acknowledgements

We thank Dr. Madeleine Carreau (Laval University) for the Fanca+/ mice, the Vector Core of the Cincinnati Children’s Research Foundation (Cincinnati Children’s Hospital Medical Center) for the preparation of retroviruses, and the Comprehensive Mouse and Cancer Core of the Cincinnati Children’s Research Foundation (Cincinnati Children’s Hospital Medical Center) for bone marrow transplantation service. This work was supported by NIH grants R01 CA193350, R01 DK104814, R01 CA150547, R01 HL076712, and R01 HD089932. Q.P. and J.M. were Leukemia and Lymphoma Scholar. W.D. was supported by the NIH T32 HL091805 training grant. The studies were further supported by a NIH center grant P30 DK090971.

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W.D. and W.L. designed and performed research, analyzed data, and wrote the paper; X.S., B.M., and J.S. performed research; M.W. and J.M. contributed vital new reagents or analytical tools; S.D. and H.G. wrote the paper; Q.P. and Y.Z. designed research, contributed vital new reagents or analytical tools, analyzed data, and wrote the paper.

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Correspondence to Wei Du or Qishen Pang or Yi Zheng.

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The authors declare that they have no conflict of interest.

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Du, W., Liu, W., Mizukawa, B. et al. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia 32, 2041–2046 (2018). https://doi.org/10.1038/s41375-018-0200-3

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