Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Chronic myelogenous leukemia

Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial

Leukemia volume 32, pages 1657–1669 (2018)Cite this article

Subjects

Abstract

A total of 156 patients (age range 1.3–18.0 years, median 13.2 years; 91 (58.3%) male) with newly diagnosed CML (N = 146 chronic phase (CML-CP), N = 3 accelerated phase (CML-AP), N = 7 blastic phase (CML-BP)) received imatinib up-front (300, 400, 500 mg/m2, respectively) within a prospective phase III trial. Therapy response, progression-free survival, causes of treatment failure, and side effects were analyzed in 148 children and adolescents with complete data. Event-free survival rate by 18 months for patients in CML-CP (median follow-up time 25 months, range: 1−120) was 97% (95% CI, 94.2−99.9%). According to the 2006 ELN-criteria complete hematologic response by month 3, complete cytogenetic response (CCyR) by month 12, and major molecular response (MMR) by month 18 were achieved in 98, 63, and 59% of the patients, respectively. By month 36, 86% of the patients achieved CCyR and 74% achieved MMR. Thirty-eight patients (27%) experienced imatinib failure because of unsatisfactory response or intolerance (N = 9). In all, 28/148 patients (19%) underwent stem cell transplantation (SCT). In the SCT sub-cohort 2/23 patients diagnosed in CML-CP, 0/1 in CML-AP, and 2/4 in CML-BP, respectively, died of relapse (N = 3) or SCT-related complications (N = 2). This large pediatric trial extends and confirms data from smaller series that first-line imatinib in children is highly effective.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Cortes J, Talpaz M, O’Brien S, Giles F, Beth RM, Shan J, et al. Effects of age on prognosis with imatinib mesylate therapy for patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Cancer. 2003;98:1105–13.

    Article  PubMed  CAS  Google Scholar 

  2. Cwynarski K, Roberts IA, Iacobelli S, van BA, Brand R, Devergie A, et al. Stem cell transplantation for chronic myeloid leukemia in children. Blood. 2003;102:1224–31.

    Article  PubMed  CAS  Google Scholar 

  3. Suttorp M, Claviez A, Bader P, Peters C, Gadner H, Ebell W, et al. Allogeneic stem cell transplantation for pediatric and adolescent patients with CML: results from the prospective trial CML-paed I. Klin Padiatr. 2009;221:351–7.

    Article  PubMed  CAS  Google Scholar 

  4. Chaudhury S, Sparapani R, Hu ZH, Nishihori T, bdel-Azim H, Malone A, et al. Outcomes of allogeneic hematopoietic cell transplantation in children and young adults with chronic myeloid leukemia: a CIBMTR cohort analysis. Biol Blood Marrow Transplant. 2016;22:1056–64.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Champagne MA, Capdeville R, Krailo M, Qu W, Peng B, Rosamilia M, et al. Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: results from a Children’s Oncology Group phase 1 study. Blood. 2004;104:2655–60.

    Article  PubMed  CAS  Google Scholar 

  6. Suttorp M, Millot F. Treatment of pediatric chronic myeloid leukemia in the year 2010: use of tyrosine kinase inhibitors and stem-cell transplantation. Hematol Am Soc Hematol Educ Program. 2010;2010:368–76.

    Google Scholar 

  7. Hijiya N, Schultz KR, Metzler M, Millot F, Suttorp M. Pediatric chronic myeloid leukemia is a unique disease that requires a different approach. Blood. 2016;127:392–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Champagne MA, Fu CH, Chang M, Chen H, Gerbing RB, Alonzo TA, et al. Higher dose imatinib for children with de novo chronic phase chronic myelogenous leukemia: a report from the Children’s Oncology Group. Pediatr Blood Cancer. 2011;57:56–62.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Millot F, Baruchel A, Guilhot J, Petit A, Leblanc T, Bertrand Y, et al. Imatinib is effective in children with previously untreated chronic myelogenous leukemia in early chronic phase: results of the French national phase IV trial. J Clin Oncol. 2011;29:2827–32.

    Article  PubMed  CAS  Google Scholar 

  10. Gurrea SD, Glauche I, Tauer JT, Thiede C, Suttorp M. Can prognostic scoring systems for chronic myeloid leukemia as established in adults be applied to pediatric patients? Ann Hematol. 2015;94:1363–71.

    Article  Google Scholar 

  11. Millot F, Guilhot J, Suttorp M, Meral Günes A, Sedlacek P, De Bont ES, et al. Prognostic discrimination based on the EUTOS long term survival score within the International Registry for Chronic Myeloid Leukemia in Children and Adolescents. Haematologica. 2017;102:1704–08.

    Article  PubMed  PubMed Central  Google Scholar 

  12. de la Fuente J, Baruchel A, Biondi A, de BE, Dresse MF, Suttorp M, et al. Managing children with chronic myeloid leukaemia (CML): recommendations for the management of CML in children and young people up to the age of 18 years. Br J Haematol. 2014;167:33–47.

    Article  PubMed  Google Scholar 

  13. Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood. 2006;108:1809–20.

    Article  PubMed  CAS  Google Scholar 

  14. Picard S, Titier K, Etienne G, Teilhet E, Ducint D, Bernard MA, et al. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood. 2007;109:3496–9.

    Article  PubMed  CAS  Google Scholar 

  15. Burmeister T, Maurer J, Aivado M, Elmaagacli AH, Grunebach F, Held KR, et al. Quality assurance in RT-PCR-based BCR/ABL diagnostics—results of an interlaboratory test and a standardization approach. Leukemia. 2000;14:1850–6.

    Article  PubMed  CAS  Google Scholar 

  16. Branford S, Hughes T. Detection of BCR-ABL mutations and resistance to imatinib mesylate. Methods Mol Med. 2006;125:93–106.

    PubMed  CAS  Google Scholar 

  17. Müller MC, Cross NC, Erben P, Schenk T, Hanfstein B, Ernst T, et al. Harmonization of molecular monitoring of CML therapy in Europe. Leukemia. 2009;23:1957–63.

    Article  PubMed  CAS  Google Scholar 

  18. Cross NC, White HE, Colomer D, Ehrencrona H, Foroni L, Gottardi E, et al. Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia. Leukemia. 2015;29:999–1003.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Branford S, Fletcher L, Cross NC, Muller MC, Hochhaus A, Kim DW, et al. Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials. Blood. 2008;112:3330–8.

    Article  PubMed  CAS  Google Scholar 

  20. Saußele S, Richter J, Hochhaus A, Mahon FX. The concept of treatment-free remission in chronic myeloid leukemia. Leukemia. 2016;30:1638–47.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. Ross DM, Hughes TP. How I determine if and when to recommend stopping tyrosine kinase inhibitor treatment for chronic myeloid leukaemia. Br J Haematol. 2014;166:3–11.

    Article  PubMed  CAS  Google Scholar 

  22. Mahon FX, Réa D, Guilhot J, Guilhot F, Huguet F, Nicolini F, et al.on behalf of the Intergroupe Français des Leucémies Myéloïdes Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010;11:1029–35.

    Article  PubMed  CAS  Google Scholar 

  23. Baccarani M. Managing children with chronic myeloid leukaemia. Br J Haematol. 2015;169:759–60.

    Article  PubMed  Google Scholar 

  24. Millot F, Suttorp M. Managing children with chronic myeloid leukaemia—response to Baccarani. Br J Haematol. 2015;169:760–1.

    Article  PubMed  Google Scholar 

  25. Moser O, Krumbholz M, Thiede C, Tauer JT, Janz I, Lauten M, et al. Sustained complete molecular remission after imatinib discontinuation in children with chronic myeloid leukemia. Pediatr Blood Cancer. 2014;61:2080–2.

    Article  PubMed  CAS  Google Scholar 

  26. Menon-Andersen D, Mondick JT, Jayaraman B, Thompson PA, Blaney SM, Bernstein M, et al. Population pharmacokinetics of imatinib mesylate and its metabolite in children and young adults. Cancer Chemother Pharmacol. 2009;63:229–38.

    Article  PubMed  CAS  Google Scholar 

  27. Giona F, Putti MC, Micalizzi C, Menna G, Moleti ML, Santoro N, et al. Long-term results of high-dose imatinib in children and adolescents with chronic myeloid leukaemia in chronic phase: the Italian experience. Br J Haematol. 2015;170:398–407.

    Article  PubMed  CAS  Google Scholar 

  28. Ganta RR, Nasaka S, Gundeti S. Impact of imatinib adherence on the cytogenetic response in pediatric chronic myeloid leukemia—chronic phase. Indian J Pediatr. 2016;83:1009–12.

    Article  PubMed  Google Scholar 

  29. Linga VG, Ganta RR, Kalpathi KI, Gundeti S, Rajappa SJ, Digumarti R, et al. Response to imatinib mesylate in childhood chronic myeloid leukemia in chronic phase. South Asian J Cancer. 2014;3:203–5.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Druker BJ, Guilhot F, O’Brien SG, Gathmann I, Kantarjian H, Gattermann N, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355:2408–17.

    Article  PubMed  CAS  Google Scholar 

  31. Kantarjian H, Shah NP, Hochhaus A, Cortes J, Shah S, Ayala M, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2010;362:2260–70.

    Article  PubMed  CAS  Google Scholar 

  32. Saglio G, Kim DW, Issaragrisil S, le CP, Etienne G, Lobo C, et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med. 2010;362:2251–9.

    Article  PubMed  CAS  Google Scholar 

  33. Hehlmann R, Lauseker M, Jung-Munkwitz S, Leitner A, Muller MC, Pletsch N, et al. Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-alpha in newly diagnosed chronic myeloid leukemia. J Clin Oncol. 2011;29:1634–42.

    Article  PubMed  CAS  Google Scholar 

  34. El-Alfy MS, Al-Haddad AM, Hamed AA. Management of CML in the pediatric age group: imatinib mesylate or SCT. J Egypt Natl Canc Inst. 2010;22:227–32.

    PubMed  Google Scholar 

  35. Lakshmaiah KC, Bhise R, Purohit S, Abraham LJ, Lokanatha D, Suresh TM, et al. Chronic myeloid leukemia in children and adolescents: results of treatment with imatinib mesylate. Leuk Lymphoma. 2012;53:2430–3.

    Article  PubMed  CAS  Google Scholar 

  36. Hoffmann VS, Baccarani M, Hasford J, Castagnetti F, Di Raimondo F, Casado LF, et al. Treatment and outcome of 2904 CML patients from the EUTOS population-based registry. Leukemia. 2017;31:593–601.

    Article  PubMed  CAS  Google Scholar 

  37. Pfirrmann M, Baccarani M, Saussele S, Guilhot J, Cervantes F, Ossenkoppele G, et al. Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia. Leukemia. 2016;30:48–56.

    Article  PubMed  CAS  Google Scholar 

  38. de Lavallade H, Apperley JF, Khorashad JS, Milojkovic D, Reid AG, Bua M, et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J Clin Oncol. 2008;26:3358–63.

    Article  PubMed  Google Scholar 

  39. Millot F, Claviez A, Leverger G, Corbaciglu S, Groll AH, Suttorp M. Imatinib cessation in children and adolescents with chronic myeloid leukemia in chronic phase. Pediatr Blood Cancer. 2014;61:355–7.

    Article  PubMed  Google Scholar 

  40. Zwaan CM, Rizzari C, Mechinaud F, Lancaster DL, Lehrnbecher T, van der Velden V, et al. Dasatinib in children and adolescents with relapsed or refractory leukemia: results of the CA180-018 phase I dose−escalation study of the Innovative Therapies for Children with Cancer Consortium. J Clin Oncol. 2013;31:2460–8.

    Article  PubMed  CAS  Google Scholar 

  41. Gore L, Kearns P, Lee ML, De Souza CA, Bertrand Y, Hijiya N, et al. Phase II trial of dasatinib (DAS) in pediatric patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP). (ASCO 2017 abstract). J Clin Oncol. 2017;35(15 Suppl):10511

    Article  Google Scholar 

  42. Hijiya N, Maschan A, Rizzari C, Shimada H, Dufour C, Goto H, et al. Efficacy and safety of nilotinib in pediatric patients with Philadelphia chromosome-positive (PH+) chronic myeloid leukemia (CML): results from a PHASE 2 trial. (SIOP abstract). Ped Blood Cancer. 2017;64(Suppl. 3):22–3.

    Google Scholar 

  43. Kalmanti L, Saussele S, Lauseker M, Proetel U, Muller MC, Hanfstein B, et al. Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV. Ann Hematol. 2014;93:71–80.

    Article  PubMed  Google Scholar 

  44. Hochhaus A, Larson RA, Guilhot F, Radich JP, Branford S,Hughes TP, et al.IRIS Investigators Long-term outcomes of imatinib treatment for chronic myeloid leukemia. N Engl J Med. 2017;376:917–27.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  45. Shima H, Tokuyama M, Tanizawa A, Tono C, Hamamoto K, Muramatsu H, et al. Distinct impact of imatinib on growth at prepubertal and pubertal ages of children with chronic myeloid leukemia. J Pediatr. 2011;159:676–81.

    Article  PubMed  CAS  Google Scholar 

  46. Bansal D, Shava U, Varma N, Trehan A, Marwaha RK. Imatinib has adverse effect on growth in children with chronic myeloid leukemia. Pediatr Blood Cancer. 2012;59:481–4.

    Article  PubMed  Google Scholar 

  47. Millot F, Guilhot J, Baruchel A, Petit A, Leblanc T, Bertrand Y, et al. Growth deceleration in children treated with imatinib for chronic myeloid leukaemia. Eur J Cancer. 2014;50:3206–11.

    Article  PubMed  CAS  Google Scholar 

  48. Tauer JT, Nowasz C, Sedlacek P, de Bont ES, Aleinikova O, Suttorp M, et al. Impairment of longitudinal growth by tyrosine kinase inhibitor (TKI) treatment—data from a large pediatric cohort with chronic myeloid leukemia (CML). Blood. 2014;124: ASH Abstract #522.

  49. Samis J, Lee P, Arceci RJ, Suttorp M, Hijiya N. Recognizing endocrinopathies associated with tyrosine kinase inhibitor therapy in children with chronic myelogenous leukemia. Review. Pediatr Blood Cancer. 2016;63:1332–8.

    Article  PubMed  Google Scholar 

  50. Tauer JT, Hofbauer LC, Jung R, Gerdes S, Glauche I, Erben RG, et al. Impact of long-term exposure to the tyrosine kinase inhibitor imatinib on the skeleton of growing rats. PLoS ONE. 2015;10:e0131192.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  51. O’Sullivan S, Naot D, Callon K, Porteous F, Horne A, Wattie D, et al. Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms. J Bone Miner Res. 2007;22:1679–89.

    Article  PubMed  Google Scholar 

  52. Vandyke K, Fitter S, Dewar AL, Hughes TP, Zannettino AC, Dysregulation of bone remodeling by imatinib mesylate. Blood. 2010;115:766–74.

    Article  PubMed  CAS  Google Scholar 

  53. Vandyke K, Dewar AL, Fitter S, Menicanin D, To LB, Hughes TP, et al. Imatinib mesylate causes growth plate closure in vivo. Leukemia. 2009;23:2155–9.

    Article  PubMed  CAS  Google Scholar 

  54. Narayanan KR, Bansal D, Walia R, Sachdeva N, Bhansali A, Varma N, et al. Growth failure in children with chronic myeloid leukemia receiving imatinib is due to disruption of GH/IGF-1 axis. Pediatr Blood Cancer. 2013;60:1148–53.

    Article  PubMed  CAS  Google Scholar 

  55. Deininger MW, O’Brien SG, Ford JM, Druker BJ. Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol. 2003;21:1637–47.

    Article  PubMed  CAS  Google Scholar 

  56. Jabbour E, Deininger M, Hochhaus A. Management of adverse events associated with tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia. 2011;25:201–10.

    Article  PubMed  CAS  Google Scholar 

  57. Rea D, Management of adverse events associated with tyrosine kinase inhibitors in chronic myeloid leukemia. Ann Hematol. 2015;94(Suppl 2):S149–58.

    Article  PubMed  CAS  Google Scholar 

  58. Steegmann JL, Baccarani M, Breccia M, Casado LF, García-Gutiérrez V, Hochhaus A, et al. European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia. Leukemia. 2016;30:1648–71.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  59. Holyoake TL, Vetrie D. The chronic myeloid leukemia stem cell: stemming the tide of persistence. Blood. 2017;129:1595–606.

    Article  PubMed  CAS  Google Scholar 

  60. Innes AJ, Milojkovic D, Apperley JF. Allogeneic transplantation for CML in the TKI era: striking the right balance. Nat Rev Clin Oncol. 2016;13:79–91.

    Article  PubMed  CAS  Google Scholar 

  61. Mahon FX. Treatment-free remission in CML: who, how, and why? Hematol Am Soc Hematol Educ Program. 2017;2017:102–9.

    Google Scholar 

  62. Miranda MB, Lauseker M, Kraus MP, Proetel U, Hanfstein B, Fabarius A, et al. Secondary malignancies in chronic myeloid leukemia patients after imatinib-based treatment: long-term observation in CML Study IV. Leukemia. 2016;30:1255–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  63. Kalmanti L, Saussele S, Lauseker M, Müller MC, Dietz CT, Heinrich L, et al. Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV. Leukemia. 2015;29:1123–32.

    Article  PubMed  CAS  Google Scholar 

  64. Hehlmann R, Lauseker M, Saußele S, Pfirrmann M, Krause S, Kolb HJ, et al. Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants. Leukemia. 2017;31:2398–406.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Acknowledgements

Meinolf Suttorp received financial support as grants from Deutsche Forschungsgemeinschaft (DFG SU 122/3-1), Sonnenstrahl e.V. Dresden, Germany, Peter-Escher Foundation, Leipzig, Germany, and Mitteldeutsche Kinderkrebsforschung Foundation, Leipzig, Germany. The work of Ingmar Glauche and Philipp Schulze was supported by the German Federal Ministry of Research and Education, Grant number 031A315 “MessAge” and Grant number 031A424 “HaematoOpt”.

Author information

Author notes

  1. These authors contributed equally: Brigitte Schlegelberger, Christian Thiede

Authors and Affiliations

  1. Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital “Carl Gustav Carus”, TU Dresden, Dresden, Germany

    Meinolf Suttorp, Christina Nowasz & Josephine T. Tauer

  2. Institute for Medical Informatics and Biometry, Faculty of Medicine “Carl Gustav Carus”, TU Dresden, Dresden, Germany

    Philipp Schulze & Ingmar Glauche

  3. Department of Human Genetics, Hannover Medical School, Hannover, Germany

    Gudrun Göhring, Nils von Neuhoff & Brigitte Schlegelberger

  4. Department of Pediatrics III, University Hospital, University of Duisburg-Essen, Duisberg, Germany

    Nils von Neuhoff & Bernhard Kremens

  5. Pediatric Hematology and Oncology, University Children’s Hospital, Erlangen, Germany

    Markus Metzler & Manuela Krumbholz

  6. Pediatric Hematology and Oncology, Teaching Hospital Motol, 2nd Medical School, Charles University Motol, Prague, Czech Republic

    Petr Sedlacek

  7. Pediatric Hematology and Oncology, University Children’s Hospital, Groningen, The Netherlands

    Eveline S. J. M. de Bont

  8. Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands

    Eveline S. J. M. de Bont

  9. Pediatric Hematology and Hematopoietic Stem Cell Transplantation Unit, Clinica Pediatrica Università degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy

    Adriana Balduzzi

  10. Department of Pediatric and Adolescent Medicine, University Hospital, Rigshospitalet, Copenhagen, Denmark

    Birgitte Lausen

  11. Belarus Research Center for Pediatric Oncology, Hematology, and Immunology, Minsk, Belarus

    Olga Aleinikova

  12. Department of Pediatrics, BMT Unit, Comenius University Children’s Hospital, Bratislava, Slovakia

    Sabina Sufliarska

  13. Pediatric Hematology and Oncology, University Children’s Hospital, Charité Berlin, Germany

    Günter Henze, Gabriele Strauss & Angelika Eggert

  14. Pediatric Hematology and Oncology, Helios KlinikenBerlin-Buch, Berlin, Germany

    Gabriele Strauss

  15. Pediatric Hematology and Oncology, University Children’s Hospital, Münster, Germany

    Andreas H. Groll

  16. Pediatric Hematology and Oncology, University Children’s Hospital, Cologne, Germany

    Frank Berthold

  17. University Children’s Hospital, Ludwig Maximilians University, Munich, Germany

    Christoph Klein

  18. Pediatric Oncology, Hematology, Immunology, Stuttgart Cancer Center, Klinikum Stuttgart—Olgahospital, Stuttgart, Germany

    Ute Groß-Wieltsch

  19. Paediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany

    Karl Walter Sykora

  20. Pediatric Hematology, Oncology, and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

    Arndt Borkhardt

  21. Pediatric Oncology, Hematology, and Immunology, University Children’s Hospital, Heidelberg, Germany

    Andreas E. Kulozik

  22. Pediatric Hematology and Oncology, University Children’s Hospital, Kiel, Germany

    Martin Schrappe & Alexander Claviez

  23. Shriners Hospitals for Children, Montréal, Canada

    Josephine T. Tauer

  24. Oncogenetic Laboratory, Pediatric Hematology and Oncology, University Children’s Hospital, Giessen, Germany

    Jochen Harbott

  25. Institute of Pathology, Hannover Medical School, Hannover, Germany

    Hans H. Kreipe

  26. Medical Department I, University Hospital “Carl Gustav Carus”, TU Dresden, Dresden, Germany

    Christian Thiede

Authors
  1. Meinolf Suttorp
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Philipp Schulze
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ingmar Glauche
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gudrun Göhring
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nils von Neuhoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Markus Metzler
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Petr Sedlacek
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Eveline S. J. M. de Bont
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Adriana Balduzzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Birgitte Lausen
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Olga Aleinikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Sabina Sufliarska
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Günter Henze
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Gabriele Strauss
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Angelika Eggert
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Bernhard Kremens
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Andreas H. Groll
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Frank Berthold
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Christoph Klein
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Ute Groß-Wieltsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Karl Walter Sykora
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Arndt Borkhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Andreas E. Kulozik
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Martin Schrappe
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Christina Nowasz
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. Manuela Krumbholz
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. Josephine T. Tauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. Alexander Claviez
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. Jochen Harbott
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. Hans H. Kreipe
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. Brigitte Schlegelberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. Christian Thiede
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Meinolf Suttorp.

Ethics declarations

Conflict of interest

IG received research support (Institutional) and reimbursement for attending symposia from Bristol-Myers-Squibb. HHK received research support (Institutional) from Roche Pharma, and coverage of other expenses by Amgen, Astra Zeneca, Genomic Health, Lilly, and Roche Pharma. BS received fees for advisory board consultations (PARP inhibitors, not related to this trial) from Astra Zeneca. MSch received recent research support (Institutional) from Novartis in the time period from 2004 to 2012. MS received research support (Institutional) from Novartis and reimbursement for attending symposia organized by Bristol-Myers-Squibb, Novartis, and Pfizer. CT received research support (Institutional) from Bayer, Novartis, and Roche and is employed presently as CEO by AgenDix GmbH. The remaining authors declare that they have no conflict of interest. Neither Novartis nor any other pharmaceutical company was permitted prior insight to the results of trial CML-Paed II. Apart from the authors nobody participated in writing of the manuscript.

Electronic supplementary material

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Suttorp, M., Schulze, P., Glauche, I. et al. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Leukemia 32, 1657–1669 (2018). https://doi.org/10.1038/s41375-018-0179-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41375-018-0179-9

This article is cited by

Search

Advanced search

Quick links