We are grateful to Sébastien Causse for his help with the microscopy, Jean-Paul Pais de Barros for the lipidomic study, Julien Guy for help with T-ALL sample characterization and Philip Bastable for editing and critical reading of this manuscript. This study was supported by grants from the association Laurette Fugain (RQ), the Conférence de Coordination Interrégionale du Grand Est—Bourgogne Franche-Comté (CCIRGE-BFC) de la Ligue contre le Cancer (RQ), by the National Research Agency under the program “Investissements d’Avenir” (reference ANR-11-LABX-0021, LipSTIC Labex), by the Conseil Régional de Bourgogne through the plan d’action régional pour l’innovation (PARI) and the European Union through the PO FEDER-FSE Bourgogne 2014/2020 programs. AB was supported by fellowships from the French Ministère de la Recherche et de l’Enseignement Supérieur (MRES) and LS-P by a fellowship from the Conseil Régional de Bourgogne/INSERM. FP and BU have grants from LNCC, INSERM, CEA, and Université Paris Diderot.Author contributions
AB and RQ conceived the experiments, performed the experiments, and interpreted the data; TA helped with the experiments; LS-P performed the isolation of rafts by flotation on sucrose density gradients; GL performed the proteomic study; J-NB and LD discussed the data; BU and FP provided human T-ALL xenografts and advices in the usage of such models and discussed the data; LD and FP helped with the writing of the manuscript; AB and RQ wrote the manuscript; RQ supervised the research.