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Acute lymphoblastic leukemia

Saracatinib impairs maintenance of human T-ALL by targeting the LCK tyrosine kinase in cells displaying high level of lipid rafts

Leukemiavolume 32pages20622065 (2018) | Download Citation

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We are grateful to Sébastien Causse for his help with the microscopy, Jean-Paul Pais de Barros for the lipidomic study, Julien Guy for help with T-ALL sample characterization and Philip Bastable for editing and critical reading of this manuscript. This study was supported by grants from the association Laurette Fugain (RQ), the Conférence de Coordination Interrégionale du Grand Est—Bourgogne Franche-Comté (CCIRGE-BFC) de la Ligue contre le Cancer (RQ), by the National Research Agency under the program “Investissements d’Avenir” (reference ANR-11-LABX-0021, LipSTIC Labex), by the Conseil Régional de Bourgogne through the plan d’action régional pour l’innovation (PARI) and the European Union through the PO FEDER-FSE Bourgogne 2014/2020 programs. AB was supported by fellowships from the French Ministère de la Recherche et de l’Enseignement Supérieur (MRES) and LS-P by a fellowship from the Conseil Régional de Bourgogne/INSERM. FP and BU have grants from LNCC, INSERM, CEA, and Université Paris Diderot.

Author contributions

AB and RQ conceived the experiments, performed the experiments, and interpreted the data; TA helped with the experiments; LS-P performed the isolation of rafts by flotation on sucrose density gradients; GL performed the proteomic study; J-NB and LD discussed the data; BU and FP provided human T-ALL xenografts and advices in the usage of such models and discussed the data; LD and FP helped with the writing of the manuscript; AB and RQ wrote the manuscript; RQ supervised the research.

Author information


  1. UMR1231, Inserm / Université Bourgogne Franche-Comté, Dijon, France

    • Anne Buffière
    • , Théo Accogli
    • , Laetitia Saint-Paul
    • , Jean-Noël Bastie
    • , Laurent Delva
    •  & Ronan Quéré
  2. Labex LipSTIC, Dijon, France

    • Anne Buffière
    • , Laetitia Saint-Paul
    • , Jean-Noël Bastie
    • , Laurent Delva
    •  & Ronan Quéré
  3. Plateforme de Protéomique, Université Bourgogne Franche-Comté, Dijon, France

    • Géraldine Lucchi
  4. UMR967, Inserm / CEA / Université Paris 7 / Université Paris 11, Fontenay-aux-Roses, France

    • Benjamin Uzan
    •  & Françoise Pflumio
  5. LSHL, IRCM / CEA, Fontenay-aux-Roses, France

    • Benjamin Uzan
    •  & Françoise Pflumio
  6. Assistance Publique-Hôpitaux de Paris, Laboratoire d’Hématologie, Hôpital Trousseau, Paris, France

    • Paola Ballerini
  7. Hôpital Universitaire François Mitterrand, Service d’Hématologie Clinique, Dijon, France

    • Jean-Noël Bastie
  8. Hôpital Universitaire François Mitterrand, CRB Ferdinand Cabanne, BB-0033-00044, Dijon, France

    • Jean-Noël Bastie


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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Ronan Quéré.

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