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Chronic myeloproliferative neoplasms

Ongoing clonal evolution in chronic myelomonocytic leukemia on hypomethylating agents: a computational perspective

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This work was supported by a Leukemia and Lymphoma Society (LLS) Translational Research Program Award (6086-12) (M.W.D.) and an LLS Specialized Center of Research Program Award (GCNCR0314A-UTAH) (M.W.D.). This work was also supported by the National Institutes of Health (NIH) National Cancer Institute grant R01CA178397 (M.W.D. and T.O.), the V Foundation for Cancer Research grant (M.W.D. and T.O.) and by U01HG006513 (G.T.M.). J.S.K. was a special fellow of the LLS and was supported by a Translational Research Training in Hematology Award from the American Society of Hematology (ASH). H.T. was a visiting scholar from Singapore, and was supported by the Research Training Fellowship from National Medical Research Council of Singapore. We thank Brian K. Dalley, director of High-Throughput Genomics Core Facility, and James Marvin, director of Flow Cytometry Core Facility, at the University of Utah for their assistance with the experiments. The University of Utah Flow Cytometry Facility was supported by the National Cancer Institute through award 5P30CA042014-24 and the National Center for Research Resources of the National Institutes of Health under award 1S10RR026802-01. The University of Utah High-Throughput Genomics Core Facility was supported by Award Number P30CA042014 from the National Cancer Institute.

Author contributions

H.T., Y.Q., and M.W.D. conceived the project and analyzed data. H.T., T.O., and M.W.D. wrote the manuscript. Y.Q., X.H., and G.T.M. designed the software and analyzed data. H.T., D.Y., and J.S.K. prepared the samples and performed experiments. M.W.D. and T.J.K. provided clinical information and research materials. A.D.P. and T.O. critically reviewed the manuscript.

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Correspondence to Michael W. Deininger.

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M.W.D. is on the advisory board and is a consultant for Incyte, Novartis and Pfizer, and serves on the advisory board for Ariad, Blueprint, and Galena BioPharma. His laboratory receives research funding from Novartis and Pfizer.

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Than, H., Qiao, Y., Huang, X. et al. Ongoing clonal evolution in chronic myelomonocytic leukemia on hypomethylating agents: a computational perspective. Leukemia 32, 2049–2054 (2018).

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