Brief Communication

Acute Myeloid Leukemia

Germline alterations in a consecutive series of acute myeloid leukemia

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Acknowledgements

This study was funded by grants from the Academy of Finland (#274474, #312492, and #284538), the Sigrid Juselius Foundation, Helsinki University Hospital Comprehensive Cancer Research Funding, and The Finnish Funding Agency for Technology and Innovation (TEKES). We are extremely grateful to patients who participated and thus made this study possible. We thank FuGU and the FIMM Technology Center for excellent exome/Sanger sequencing services; Minna Suvela, Siv Knaappila, Annukka Ruokolainen, and Pihla Siipola for excellent technical assistance. The Aaltonen laboratory, especially Riku Katainen, is thanked for help in bioinformatics and the exome control files.

Author contributions

OK and UW-K designed the study. UW-K collected the clinical data, analyzed the results, and drafted the manuscript. EAMH analyzed the exome data, validated the mutations, and drafted the manuscript together with OK and UW-K. EP brought new ideas to the data analysis and contributed to the statistical analyses. JS, KK, and CH organized the exome sequencing at FIMM. KP organized the exome sequencing and major funding for the project. All authors have read and approved the manuscript.

Author information

Author notes

  1. These authors contributed equally: Ulla Wartiovaara-Kautto, Elina A. M. Hirvonen.

Affiliations

  1. Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland

    • Ulla Wartiovaara-Kautto
    •  & Kimmo Porkka
  2. Genome-Scale Biology/Research Programs Unit, and Department of Medical and Clinical Genetics/Medicum, University of Helsinki, Helsinki, Finland

    • Elina A. M. Hirvonen
    •  & Outi Kilpivaara
  3. Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

    • Esa Pitkänen
  4. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

    • Caroline Heckman
    • , Janna Saarela
    •  & Kaisa Kettunen
  5. Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland

    • Kimmo Porkka

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Outi Kilpivaara.

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