Clements PJ, Hurwitz EL, Wong WK, et al. Skin thickness score as a predictor and correlate of outcome in systemic sclerosis: high-dose versus low-dose penicillamine trial. Arthritis Rheum. 2000;43:2445–54.
Steen VD, Medsger TA Jr. Improvement in skin thickening in systemic sclerosis associated with improved survival. Arthritis Rheum. 2001;44:2828–35.
Ehrlich HP, Allison GM, Leggett M. The myofibroblast, cadherin, alpha smooth muscle actin and the collagen effect. Cell Biochem Funct. 2006;24:63–70.
Rosin NL, Agabalyan N, Olsen K, et al. Collagen structural alterations contribute to stiffening of tissue after split-thickness skin grafting. Wound Repair Regen. 2016;24:263–74.
Kendall RT, Feghali-Bostwick CA. Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol. 2014;5:123.
Hinz B. Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis. Curr Rheumatol Rep. 2009;11:120–6.
Philip T, Debashree S, Manish B. Two functions of lysyl oxidases: extracellular matrix maturation and cell proliferation. FASEB J. 2015;29(1_supplement):570.518
Clarke DL, Carruthers AM, Mustelin T, et al. Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes. Fibrogenes Tissue Repair. 2013;6:20.
Sethi A, Wordinger RJ, Clark AF. Gremlin utilizes canonical and non-canonical TGFbeta signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Exp Eye Res. 2013;113:117–27.
Carlson MW, Alt-Holland A, Egles C, et al. Three-dimensional tissue models of normal and diseased skin. Curr Protoc Cell Biol. 2008;Chapter 19:Unit19. 19
Matsusaki M, Fujimoto K, Shirakata Y, et al. Development of full-thickness human skin equivalents with blood and lymph-like capillary networks by cell coating technology. J Biomed Mater Res A. 2015;103:3386–96.
Maione AG, Smith A, Kashpur O, et al. Altered ECM deposition by diabetic foot ulcer-derived fibroblasts implicates fibronectin in chronic wound repair. Wound Repair Regen. 2016;24:630–43.
Marturano JE, Xylas JF, Sridharan GV, et al. Lysyl oxidase-mediated collagen crosslinks may be assessed as markers of functional properties of tendon tissue formation. Acta Biomater. 2014;10:1370–9.
Proia DA, Kuperwasser C. Reconstruction of human mammary tissues in a mouse model. Nat Protoc. 2006;1:206–14.
Quinn KP, Georgakoudi I. Rapid quantification of pixel-wise fiber orientation data in micrographs. J Biomed Opt. 2013;18:046003.
Quinn KP, Sullivan KE, Liu Z, et al. Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction. Sci Rep. 2016;6:35823.
Nakasaki M, Hwang Y, Xie Y, et al. The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis. Nat Commun. 2015;6:8574.
Zigrino P, Brinckmann J, Niehoff A, et al. Fibroblast-derived MMP-14 regulates collagen homeostasis in adult skin. J Invest Dermatol. 2016;136:1575–83.
Oh MH, Oh SY, Yu J, et al. IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol. 2011;186:7232–42.
van der Slot-Verhoeven AJ, van Dura EA, Attema J, et al. The type of collagen cross-link determines the reversibility of experimental skin fibrosis. Biochim Biophys Acta. 2005;1740:60–67.
Grover CN, Gwynne JH, Pugh N, et al. Crosslinking and composition influence the surface properties, mechanical stiffness and cell reactivity of collagen-based films. Acta Biomater. 2012;8:3080–90.
Lin S, Gu L. Influence of crosslink density and stiffness on mechanical properties of type I collagen gel. Mater (Basel). 2015;8:551–60.
Lee R, Perry B, Heywood J, et al. Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis. Front Pharmacol. 2014;5:140.
Milano A, Pendergrass SA, Sargent JL, et al. Molecular subsets in the gene expression signatures of scleroderma skin. PLoS One. 2008;3:e2696.
Marangoni RG, Varga J, Tourtellotte WG. Animal models of scleroderma: recent progress. Curr Opin Rheumatol. 2016;28:561–70.
Esch EW, Bahinski A, Huh D. Organs-on-chips at the frontiers of drug discovery. Nat Rev Drug Discov. 2015;14:248–60.
Fabre KM, Livingston C, Tagle DA. Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue. Exp Biol Med. 2014;239:1073–7.
Kolodka TM, Garlick JA, Taichman LB. Evidence for keratinocyte stem cells in vitro: long term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes. Proc Natl Acad Sci USA. 1998;95:4356–61.
Margulis A, Andriani F, Fusenig N, et al. Abrogation of E-cadherin-mediated adhesion induces tumor cell invasion in human skin-like organotypic culture. J Invest Dermatol. 2003;121:1182–90.
Andriani F, Margulis A, Lin N, et al. Analysis of microenvironmental factors contributing to basement membrane assembly and normalized epidermal phenotype. J Invest Dermatol. 2003;120:923–31.
Segal N, Andriani F, Pfeiffer L, et al. The basement membrane microenvironment directs the normalization and survival of bioengineered human skin equivalents. Matrix Biol: J Int Soc Matrix Biol. 2008;27:163–70.
Carlson M, Faria K, Shamis Y, et al. Epidermal stem cells are preserved during commercial-scale manufacture of a bilayered, living cellular construct (Apligraf(R)). Tissue Eng Part A. 2011;17:487–93.
Shamis Y, Hewitt KJ, Carlson MW, et al. Fibroblasts derived from human embryonic stem cells direct development and repair of 3D human skin equivalents. Stem Cell Res & Ther. 2011;2:10.
Beyer C, Schett G, Distler O, et al. Animal models of systemic sclerosis: prospects and limitations. Arthritis Rheum. 2010;62:2831–44.
Ruzek MC, Jha S, Ledbetter S, et al. A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease. Arthritis Rheum. 2004;50:1319–31.
Yamamoto T, Katayama I. Vascular changes in bleomycin-induced scleroderma. Int J Rheumatol. 2011;2011:270938.
Yang X, Liu C, Fujino M, et al. A modified graft-versus-host-induced model for systemic sclerosis, with pulmonary fibrosis in Rag2-deficient mice. FEBS Open Bio. 2017;7:1316–27.
Whitfield ML, Finlay DR, Murray JI, et al. Systemic and cell type-specific gene expression patterns in scleroderma skin. Proc Natl Acad Sci USA. 2003;100:12319–24.
Gardner H, Shearstone JR, Bandaru R, et al. Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum. 2006;54:1961–73.
Lagares D, Santos A, Grasberger PE, et al. Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. Sci Transl Med 2017;9.
Yang Y, Yan F, Wang L, et al. Quantification of skin stiffness in patients with systemic sclerosis using real-time shear wave elastography: a preliminary study. Clin Exp Rheumatol. 2018;36 Suppl 113:118–25.
Dunn AK, Wallace VP, Coleno M, et al. Influence of optical properties on two-photon fluorescence imaging in turbid samples. Appl Opt. 2000;39:1194–201.
Vishwanath K, Pogue B, Mycek MA. Quantitative fluorescence lifetime spectroscopy in turbid media: comparison of theoretical, experimental and computational methods. Phys Med Biol. 2002;47:3387–405.
Cox TR, Erler JT. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. Dis Model Mech. 2011;4:165–78.
Bondareva A, Downey CM, Ayres F, et al. The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells. PLoS One. 2009;4:e5620.
Hornstra IK, Birge S, Starcher B, et al. Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem. 2003;278:14387–93.
Liu X, Zhao Y, Gao J, et al. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004;36:178–82.
Martin A, Salvador F, Moreno-Bueno G, et al. Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression. EMBO J. 2015;34:1090–109.
Zhang J, Yang R, Liu Z, et al. Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice. Hum Mol Genet. 2015;24:6174–85.
Rimar D, Rosner I, Nov Y, et al. Brief report: lysyl oxidase is a potential biomarker of fibrosis in systemic sclerosis. Arthritis Rheumatol. 2014;66:726–30.
Chen SJ, Yuan W, Mori Y, et al. Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3. J Invest Dermatol. 1999;112:49–57.
Ghosh AK, Yuan W, Mori Y, et al. Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators. Oncogene. 2000;19:3546–55.
Bhattacharyya S, Tamaki Z, Wang W, et al. FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling. Sci Transl Med. 2014;6:232ra250.
Kohan M, Muro AF, White ES, et al. EDA-containing cellular fibronectin induces fibroblast differentiation through binding to alpha4beta7 integrin receptor and MAPK/Erk 1/2-dependent signaling. FASEB J. 2010;24:4503–12.
Gao AE, Sullivan KE, Black LD 3rd. Lysyl oxidase expression in cardiac fibroblasts is regulated by alpha2beta1 integrin interactions with the cellular microenvironment. Biochem Biophys Res Commun. 2016;475:70–75.
Shamis Y, Hewitt KJ, Bear SE, et al. iPSC-derived fibroblasts demonstrate augmented production and assembly of extracellular matrix proteins. Vitr Cell Dev Biol Anim. 2012;48:112–22.