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Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study

Abstract

Objective

To explore the association between antenatal magnesium sulfate (MgSO4), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants.

Study design

Retrospective, cohort study of infants <32 weeks’ GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities.

Results

7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49–0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50–0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72–1.71]). No differences between groups were observed in rates of morbidities.

Conclusion

Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.

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Acknowledgements

Authors would like to thank all the NEOCOSUR Neonatal Network members who took part in this study and the Database Unit.

NEOCOSUR Neonatal Network

Catalina Vaz Ferreira1, Jose Caro2, Luis Villarroel3, Patricia Alvarez2, Gerardo Flores2, Tamara Herrera1, Alberto Toso5, Paulina Toso5, Jose L. Tapia5

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Authors

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Contributions

Catalina Vaz Ferreira: Conceptualization, investigation, writing- original draft and visualization. José Caro: Conceptualization, methodology, investigation, writing- review and editing. Luis Villarroel: Methodology, software, formal analysis, and validation. Sergio Muñoz: Investigation. Patricia Alvarez: Investigation. Gerardo Flores: Investigation. Tamara Herrera: Investigation. Alberto Toso: Conceptualization, investigation, writing- review and editing and supervision. Paulina Toso: Investigation and supervision. José LTapia: Conceptualization, methodology, writing-review and editing, supervision, and project administration.

Corresponding author

Correspondence to Catalina Vaz Ferreira.

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Members of the NEOCOSUR Neonatal Network are listed below Acknowledgements.

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Vaz Ferreira, C., Caro, J., Villarroel, L. et al. Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study. J Perinatol (2024). https://doi.org/10.1038/s41372-024-02025-y

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  • DOI: https://doi.org/10.1038/s41372-024-02025-y

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