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Health-related quality of life at age 10 years in children born extremely preterm



To evaluate the association between prenatal maternal health and socioeconomic status (SES) and health-related quality of life (QoL) among 10-year-old children born extremely preterm.

Design/ methods

Retrospective analysis of the Extremely Low Gestational Age Newborns (ELGAN) Study cohort of infants born < 28 weeks gestational age. QoL was assessed at 10 years of age using the Pediatric Quality of Life Inventory. Multivariate regression models were used for analyses.


Of 1198 participants who survived until 10 years of age, 889 (72.2%) were evaluated. Lower maternal age, lack of college education; receipt of public insurance and Supplemental Nutrition Assistance Program (SNAP) were associated with lower QoL scores. Specific maternal health factors were also associated with lower child QoL scores.


Specific, potentially modifiable, maternal health and social factors are associated with lower scores on a measure of parent-reported child QoL across multiple domains for children born extremely preterm.

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Data availability

The dataset used for this study is not publicly available as it contains some identifiable information, but is available from the corresponding author on reasonable request.


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Dr. Msall’s efforts were also supported in part by funding from The Health Resources and Services Administration of the US Department of Health and Human Services (UA6MC32492), the Life Course Intervention Research Network. Preterm Research Node: Engaging Families of Preterm Babies to Optimize Thriving and Well-Being.


This study was supported by the National Institute of Neurological Disorders and Stroke (grants 5U01NS040069-05 and 2R01NS040069-09) and the Office of the Director of the National Institutes of Health (1UG3OD023348-01). Dr. Frazier has had research support from Healx, Quadrant, and Tetra Pharmaceuticals. All other authors have no financial relationships or any other conflicts of interest relevant to this article to disclose.

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Authors and Affiliations



CC, TMO and RS drafted the original manuscript and conceived and designed the study, contributed to data acquisition and analysis, and finalized the manuscript. AO contributed to data analysis; critically reviewed and revised the manuscript for intellectual content. ETJ, JAF, RV, JS, SG, MEM, SK, IJ and RCF contributed to data acquisition and analysis; critically reviewed and revised the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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Correspondence to Rachana Singh.

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Call, C., Oran, A., O’Shea, T.M. et al. Health-related quality of life at age 10 years in children born extremely preterm. J Perinatol 44, 835–843 (2024).

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