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Associations of salivary aldosterone levels during pregnancy with maternal blood pressure and birth weight-for-gestational age in a Mexico City birth cohort



To determine associations of maternal salivary aldosterone with blood pressure (BP) in pregnancy and infant birth weight-for-gestational age (BWGA).


We measured maternal salivary aldosterone, BP and BWGA z-scores in 471 Mexico City pregnancy cohort participants and performed multivariable linear regression of BP and BWGA on log-aldosterone levels.


Log-aldosterone was positively associated with diastolic BP (β = 0.12 95% CI: 0.04, 0.21). There were no main effects of log-aldosterone on BWGA. However, we detected an interaction between log-aldosterone and BP in association with BWGA; higher log-aldosterone was associated with lower BWGA in the lowest (β = −0.12, 95% CI: -0.26, 0.02) and highest (β = −0.12, 95% CI: −0.29, 0.06) BP tertiles. In contrast, in the middle BP tertile the association was positive (β = 0.09, 95% CI: −0.02, 0.20), p for interaction = 0.03.


Higher maternal salivary aldosterone is positively associated with diastolic BP and may affect fetal growth differently depending on concurrent maternal blood pressure.

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Fig. 1: Associations of maternal salivary aldosterone with systolic and diastolic blood pressures in the second trimester; effect estimates per SD increment of log-transformed aldosterone.

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Data availability

The data used to support the findings of this study is available from the corresponding authors upon reasonable request.


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This work was supported in part by funding from the NIH/NIEHS: R01ES01744-13, 1R24ES028522-03, R01ES013744, and R01ES014930.

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The authors’ responsibilities were as follows: designed the original study and follow-up as a birth cohort; ROW, MMTR, MTO, ASP; investigation and data curation KS, AMG and HB; conceptualized, designed and conducted secondary analyses; OGV, MTO, EOP, HB and ACA; OGV and EOP performed the statistical analysis; OGV, ACA, MTO and HB wrote the initial drafts; OGV, MTO, EOP, ACA and MMTR contributed substantially to analyses interpretation and subsequent drafts, and all authors have read and agreed to the published version of the manuscript.

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Correspondence to Ana Carolina Ariza.

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Galván-Valencia, O., Sanders, A.P., Ariza, A.C. et al. Associations of salivary aldosterone levels during pregnancy with maternal blood pressure and birth weight-for-gestational age in a Mexico City birth cohort. J Perinatol 44, 643–649 (2024).

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