To quantify the association between necrotizing enterocolitis (NEC) and neurodevelopmental disability (NDI) in extremely low birth weight (ELBW) infants with intraventricular hemorrhage (IVH).
ELBW survivors born 2011–2017 and evaluated at 16–26 months corrected age in the Vermont Oxford Network (VON) ELBW Follow-Up Project were included. Logistic regression determined the adjusted relative risk (aRR) of severe NDI in medical or surgical NEC compared to no NEC, stratified by severity of IVH.
Follow-up evaluation occurred in 5870 ELBW survivors. Compared to no NEC, medical NEC had no impact on NDI, regardless of IVH status. Surgical NEC increased risk of NDI in patients with no IVH (aRR 1.69; 95% CI 1.36–2.09), mild IVH (aRR 1.36;0.97–1.92), and severe IVH (aRR 1.35;1.13–1.60).
ELBW infants with surgical NEC carry increased risk of neurodevelopmental disability within each IVH severity stratum. These data describe the additive insult of surgical NEC and IVH on neurodevelopment, informing prognostic discussions and highlighting the need for preventative interventions.
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We thank our colleagues who submit data to VON on behalf of infants and their families. Abstract previously presented at the annual meeting of the American Pediatric Surgical Association (APSA).
JDH, RFS, and KAM are employees of the Vermont Oxford Network. EME receives salary support from Vermont Oxford Network. The remaining authors do not have financial relationships to disclose.
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Culbreath, K., Keefe, G., Nes, E. et al. Association between neurodevelopmental outcomes and concomitant presence of NEC and IVH in extremely low birth weight infants. J Perinatol (2023). https://doi.org/10.1038/s41372-023-01780-8