To determine the sensitivity and specificity of the 21-month neurodevelopmental outcome for predicting the presence of neurodevelopmental impairment at 36 months corrected age in a population of preterm infants under 29 weeks gestation.
This is a retrospective observational cohort study. Preterm infants born under 29 weeks gestation who were followed up at both 18–21 months and 36 months corrected age with outcome data available were enrolled.
Overall, 713 preterm infants <29 weeks gestation and were included in the final analysis. The specificity of the 21-month assessment for predicting neurodevelopmental impairment at 36 months corrected age was 66% (95% confidence interval[CI] 62–71%) with a positive predictive value of 61% (95% CI 56–66%).
In preterm neonates born <29 weeks gestation, the 18–21 months corrected neurodevelopmental outcome had low specificity and positive predictive value for predicting the presence of neurodevelopmental impairment at 36 months corrected age.
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We thank the Department of Pediatrics, Alberta Children’s Hospital and Neonatal Follow-up Clinic program for ongoing research support.
The authors declare no competing interests.
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Additional Information Please note that in accordance with the Alberta Health Services Data Disclosure Agreement, we are not able to provide or make available the data for any purpose to a third party without the prior written consent of Alberta Health Services, Calgary, Alberta.
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Doucette, S.M., Tang, S., Kehler, H. et al. Utility of the 21-month neurodevelopmental outcome for predicting neurodevelopmental impairment at 36 months for preterm infants <29 weeks gestation. J Perinatol 43, 1406–1412 (2023). https://doi.org/10.1038/s41372-023-01777-3