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Does enteral zinc supplementation affect growth and neurodevelopment in preterm infants?

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  1. Alshaikh B, Abo Zeed M, Yusuf K, Guin M, Fenton T. Effect of enteral zinc supplementation on growth and neurodevelopment of preterm infants: a systematic review and meta-analysis. J Perinatol. 2022;42:430–9.

    Article  CAS  PubMed  Google Scholar 

  2. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336:924–6.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Giles E, Doyle LW. Zinc in extremely low-birthweight or very preterm infants. NeoReviews. 2007;8:e165–e72.

    Article  Google Scholar 

  5. Willoughby JL, Bowen CN. Zinc deficiency and toxicity in pediatric practice. Curr Opin Pediatr. 2014;26:579–84.

    Article  CAS  PubMed  Google Scholar 

  6. Imdad A, Bhutta ZA. Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool. BMC Public Health. 2011;11:S22.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Mayo-Wilson E, Junior JA, Imdad A, Dean S, Chan XH, Chan ES, et al. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Cochrane Database Syst Rev. 2014;CD009384.

  8. Staub E, Evers K, Askie LM. Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates. Cochrane Database Syst Rev. 2021;CD012797.

  9. Lin L. Comparison of four heterogeneity measures for meta-analysis. J Eval Clin Pr. 2020;26:376–84.

    Article  Google Scholar 

  10. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Bmj 2003;327:557–60.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Hatala R, Keitz S, Wyer P, Guyatt G, Evidence-Based Medicine Teaching Tips Working G. Tips for learners of evidence-based medicine: 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results. CMAJ 2005;172:661–5.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Borenstein M, Higgins JP, Hedges LV, Rothstein HR. Basics of meta-analysis: I(2) is not an absolute measure of heterogeneity. Res Synth Methods. 2017;8:5–18.

    Article  PubMed  Google Scholar 

  13. Rücker G, Schwarzer G, Carpenter JR, Schumacher M. Undue reliance on I(2) in assessing heterogeneity may mislead. BMC Med Res Methodol. 2008;8:79.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Rosenblad A. Introduction to meta-analysis by Michael Borenstein, Larry V. Hedges, Julian P.T. Higgins, Hannah R. Rothstein. Int Stat Rev. 2009;77:478–9.

    Article  Google Scholar 

  15. Identifying and quantifying heterogeneity. Introduction to meta‐analysis 2009. p. 107-25.

  16. Hak T, van Rhee H, Suurmond R. How to interpret results of meta-analysis. SSRN Electr J. 2016.

  17. Thorlund K, Imberger G, Johnston BC, Walsh M, Awad T, Thabane L, et al. Evolution of heterogeneity (I2) estimates and their 95% confidence intervals in large meta-analyses. PLoS One. 2012;7:e39471.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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The Journal Club is a collaboration between the American Academy of Pediatrics—Section of Neonatal Perinatal Medicine and the International Society for Evidence-Based Neonatology (

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PVC: performed literature search, critical appraisal, and wrote the primary draft. RSR: advised on the content of the paper and revised the primary draft. All authors agree on the final paper as submitted and agree to be accountable for all aspects of work.

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Correspondence to Priya V. Creed.

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Creed, P.V., Rose, R.S. Does enteral zinc supplementation affect growth and neurodevelopment in preterm infants?. J Perinatol 43, 823–826 (2023).

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