Abstract
Objective
Compare Neonatal Opioid Withdrawal Syndrome (NOWS) in preterm and term infants.
Study design
Single center, retrospective chart review of all in-utero opioid exposed infants born between 2014 and 2019. Withdrawal symptoms were assessed using Modified Finnegan Assessment Tool.
Results
Thirteen preterm (PT), 72 late preterm (LPT), and 178 term infants were included. Preterm and LPT compared to term infants had lower peak Finnegan scores (9/9 vs. 12) and received less pharmacologic treatment (23.1/44.4 vs. 66.3%). Similar onset, peak symptoms, and treatment duration was observed in LPT and term infants.
Conclusions
Preterm and LPT infants have lower Finnegan scores and require less pharmacologic therapy for NOWS. It is unclear if this is because our current assessment tool does not capture their symptoms or if they truly have less withdrawal. Onset of NOWS is similar in LPT and term infant, thus LPT infants do not require prolonged hospital monitoring for NOWS.
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Data availability
The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
We thank—Michele Walsh for helping inspire the concept for this project; as well as Leslie Clark and Abigail Gibbs for contributions and assistance during this project. This research project was funded the Fellows Research Awards Programs provided by the Rainbow Babies & Children’s Foundation. Grant support from Clinical and Translational Science Award allowed for the utilizations of REDCap.
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AH, MC and LZ contributed to the conception and design of this study. AH and ACH completed the data collection. NM completed data analysis. AH, MC and AMH contributed to data analysis interpretation. AH wrote the first draft of the manuscript, with all authors revising it critically for important intellectual content. All authors approved the final version to be published.
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All components of this research project adhered to the intuition’s research guidelines and ethical standards. This study was approved by the University Hospitals Institutional Review Board.
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Heyward, A., Minich, N., Hoffman, A.C. et al. Characteristics and outcomes of neonatal opioid withdrawal syndrome in preterm infants: a retrospective cohort study in the current era. J Perinatol 43, 909–915 (2023). https://doi.org/10.1038/s41372-023-01672-x
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DOI: https://doi.org/10.1038/s41372-023-01672-x