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Blood urea nitrogen, a marker for severe retinopathy of prematurity?

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.


  1. Wu C, Löfqvist C, Smith LE, VanderVeen DK, Hellström A, WINROP Consortium. Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants: a multicenter study analyzing weight velocity deviations for the prediction of retinopathy of prematurity. Arch Ophthalmol. 2012;130:992–9.

    Article  Google Scholar 

  2. Kim SJ, Port AD, Swan R, Campbell JP, Chan RVP, Chiang MF. Retinopathy of prematurity: a review of risk factors and their clinical significance. Surv Ophthalmol. 2018;63:618–37.

    Article  Google Scholar 

  3. VanderVeen DK, Martin CR, Mehendale R, Allred EN, Dammann O, Leviton A. ELGAN Study Investigators. Early nutrition and weight gain in preterm newborns and the risk of retinopathy of prematurity. PLoS ONE. 2013;8:e64325.

    Article  CAS  Google Scholar 

  4. Singh C, Hoppe G, Tran V, McCollum L, Bolok Y, Song W, et al. Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity. JCI Insight. 2019;4:e129398.

    Article  Google Scholar 

  5. Paris LP, Johnson CH, Aguilar E, Usui Y, Cho K, Hoang LT, et al. Global metabolomics reveals metabolic dysregulation in ischemic retinopathy. Metabolomics. 2016;12:15.

    Article  CAS  Google Scholar 

  6. Bueva A, Guignard JP. Renal function in preterm neonates. Pediatr Res. 1994;36:572–7.

    Article  CAS  Google Scholar 

  7. Pierce EA, Foley ED, Smith LE. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol. 1996;114:1219–28.

    Article  CAS  Google Scholar 

  8. Hard AL, Smith LE, Hellstrom A. Nutrition, insulin-like growth factor-1 and retinopathy of prematurity. Semin fetal neonatal Med. 2013;18:136–42.

    Article  Google Scholar 

  9. Weintraub AS, Blanco V, Barnes M, Green RS. Impact of renal function and protein intake on blood urea nitrogen in preterm infants in the first 3 weeks of life. J Perinatol. 2015;35:52–6.

  10. Singh C, Tran V, McCollum L, Bolok Y, Allan K, Yuan A, et al. Hyperoxia induces glutamine-fuelled anaplerosis in retinal Muller cells. Nat Commun. 2020;11:1277.

    Article  CAS  Google Scholar 

  11. Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, et al. Muller cells in the healthy and diseased retina. Prog Retin Eye Res. 2006;25:397–424.

    Article  CAS  Google Scholar 

  12. Hard AL, Smith LE, Hellstrom A. Nutrition, insulin-like growth factor-1 and retinopathy of prematurity. Semin Fetal Neonatal Med. 2013;18:136–42.

    Article  Google Scholar 

  13. Haussinger D, Lamers WH, Moorman AF. Hepatocyte heterogeneity in the metabolism of amino acids and ammonia. Enzyme. 1992;46:72–93.

    Article  CAS  Google Scholar 

  14. Zhou Y, Xu Y, Zhang X, Huang Q, Tan W, Yang Y, et al. Plasma levels of amino acids and derivatives in retinopathy of prematurity. Int J Med Sci. 2021;18:3581–7.

    Article  CAS  Google Scholar 

  15. Yang Y, Yang Q, Luo S, Zhang Y, Lian C, He H, et al. Comparative analysis reveals novel changes in plasma metabolites and metabolomic networks of infants with retinopathy of prematurity. Investig Ophthalmol Vis Sci. 2022;63:28.

    Article  CAS  Google Scholar 

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Authors and Affiliations



AD, HA and JES conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. IB and FH collected data, carried out the initial analyses, and reviewed the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Anirudha Das.

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Competing interests

The authors declare no competing interests.

Consent statement

The need for consent was waived for this study by the IRB.

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Das, A., Bhattacharjee, I., Heis, F. et al. Blood urea nitrogen, a marker for severe retinopathy of prematurity?. J Perinatol (2023).

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