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Neonatal respiratory support related to lung function abnormalities in school-age children with bronchopulmonary dysplasia



To elucidate the relationship between abnormal lung function (LF) at school age and neonatal respiratory support in very low birth weight children with bronchopulmonary dysplasia (BPD).

Study design

We retrospectively examined 78 BPD children whose LF was evaluated at 8–9 years. LF abnormalities were defined by reduced values of spirometric parameters. Adjusted odds ratios (aORs) for abnormal LF by the type and postmenstrual age (PMA) of respiratory support were calculated using logistic regression analysis after controlling perinatal factors.


Overall, 24 (31%) patients had LF abnormalities. Antenatal steroid use was associated with a decreased risk of abnormal LF [aOR, 0.31; 95% CI, 0.09–0.92]. Requiring positive-pressure support at 37 weeks’ PMA correlated with abnormal LF [aOR, 4.58; 95% CI, 1.15–21.90]; whereas only low-flow oxygen at any PMA did not.


Requiring positive-pressure support at 37 weeks’ PMA could be an indicator of abnormal LF at school age.

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Fig. 1: Flow chart of the study participants.
Fig. 2: Distribution of LF assessed at 8–9 years of age in 78 VLBW children with BPD.

Data availability

All data relevant to the study are included in the article or supplied as supplementary information.


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The authors are grateful to clinical laboratory technicians at Jichi Medical University Hospital for conducting LF testing. No funding was secured for this study.

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Authors and Affiliations



YS contributed to the study design, methodology, investigation, data curation, and formal analysis as well as drafted the initial manuscript. YK contributed to the study design and methodology, provided supervision and resources, and drafted and revised the manuscript. YY provided supervision and revised the manuscript. HS, MM, SK, and MS contributed to data curation and revised the manuscript. TY provided supervision and revised the manuscript.

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Correspondence to Yume Suzuki.

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Suzuki, Y., Kono, Y., Yada, Y. et al. Neonatal respiratory support related to lung function abnormalities in school-age children with bronchopulmonary dysplasia. J Perinatol 43, 337–344 (2023).

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