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The dilemma of feeding during the treatment of patent ductus arteriosus with oral ibuprofen in preterm infants ≤30 weeks of gestation—a randomized controlled trial



To evaluate the effect of minimal enteral feeding (MEN) versus withholding feeding on time to reach full feeds during treatment of hs-PDA with oral ibuprofen in infants ≤30 weeks.

Study design

We performed a single-center, randomized control trial of 126 premature infants born ≤30 weeks gestation, <7 days of age with hs-PDA comparing continuation of MEN (n = 64) vs no feeding (n = 62) during treatment. The primary outcome was time to reach a feed volume of 150 ml/kg/day. Secondary outcomes included were episodes of feed intolerance, GI bleed, NEC and other comorbidities.


There was no difference in the time to reach full feeds - median age of 16 days in both groups (p = 0.573). Incidence of feed intolerance, NEC and other secondary outcomes were also similar in both groups.


Continuing MEN during treatment of hs-PDA with oral ibuprofen does not decrease time to reach full enteral feeds in very preterm infants.

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Fig. 1: Consort flow diagram.
Fig. 2


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We are thankful to the Dean of the institution for allowing us to conduct and publish our data. We also wish to thank Dr Nandkishor Kabra for critical review of the manuscript.

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Authors and Affiliations



SM conceived the study. SK, SM, JM, PK, TK and SP developed study protocol. SK, PK, TK and SP implemented the study and SM and JM supervised implementation. SK, PK, TK and SP contributed to data collection and analysis. SM and JM contributed to data interpretation. SM, PK, TK and SP wrote the initial draft while SM and JM edited the final manuscript. All authors have reviewed the manuscript and approve the submitted version. All authors meet the criteria for authorship.

Corresponding author

Correspondence to Swati Manerkar.

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Competing interests

The authors declare no competing interests.

Ethics approval

Institutional Ethics Committee, Lokmanya Tilak Municipal medical College & General Hospital, Mumbai (IEC/90/19). The study was performed in accordance with the Declaration of Helsinki.

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Kaur, S., Manerkar, S., Mondkar, J. et al. The dilemma of feeding during the treatment of patent ductus arteriosus with oral ibuprofen in preterm infants ≤30 weeks of gestation—a randomized controlled trial. J Perinatol 43, 203–208 (2023).

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