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Intrahepatic cholestasis and small for gestational age: a retrospective cohort study

Journal of Perinatology volume 43, pages 238–239 (2023)Cite this article

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Intrahepatic cholestasis of pregnancy (ICP), occurring in approximately 0.2–2% of pregnancies, is the most common pregnancy-specific liver disease [1]. ICP has been associated with adverse pregnancy outcomes including preterm delivery, meconium-stained amniotic fluid, and stillbirth [1] In pregnancies with ICP, high levels of bile acids are associated with adverse fetal outcomes including stillbirth [2].

Studies on ICP demonstrate conflicting results regarding associations between ICP and small for gestational age (SGA) birthweight. SGA is an independent risk factor for stillbirth [3] We hypothesized that pregnancies with ICP would have an increased incidence of small for gestational age (SGA) compared to pregnancies without ICP.

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References

  1. Society of Maternal-Fetal Medicine (SMFM), Lee RH, Greenberg M, Metz TD, Pettker CM. Intrahepatic cholestasis of pregnancy. Am J Obstet Gynecol. 2021;224:B2–B9.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Bethany M. Mulla, Anna M. Modest & Brett C. Young

  2. Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA, USA

    Bethany M. Mulla, Anna M. Modest & Brett C. Young

Authors
  1. Bethany M. Mulla
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  2. Anna M. Modest
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  3. Brett C. Young
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Contributions

BMM: conceptualization, methodology, investigation, writing—original draft, final approval. AMM: conceptualization, methodology, formal analysis, writing-review and editing, final approval. BCY: conceptualization, methodology, investigation, writing-review, editing, final approval.

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Correspondence to Brett C. Young.

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The authors declare no competing interests.

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Mulla, B.M., Modest, A.M. & Young, B.C. Intrahepatic cholestasis and small for gestational age: a retrospective cohort study. J Perinatol 43, 238–239 (2023). https://doi.org/10.1038/s41372-022-01590-4

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  • DOI: https://doi.org/10.1038/s41372-022-01590-4

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