Newborns in NICUs experience many painful procedures. The aim of the study was to evaluate the effect of whole body massage therapy on pain scores during venipuncture and to compare with oral 10% dextrose and Kangaroo care.
Newborns with gestational age ≥34 weeks were randomly enrolled to one of three groups: dextrose, massage and Kangaroo care and a blinded investigator scored the pain using NIPS before and during the procedure.
There were 25, 26 and 23 newborns in dextrose, massage and Kangaroo care groups, respectively. Pain scores were similar before and during venipuncture in groups (p > 0.05). 36.5% of newborns (27/74) had severe pain scores. Number of newborns with no pain (score 0–2), moderate pain (score 3–4) and severe pain (score 5–7) were similar in each group.
Massage, Kangaroo and oral 10% dextrose had similar effects on pain scores during venipuncture.
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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. All data generated or analyzed during this study are included in this published article.
Schneider J, Duerden EG, Guo T, Ng K, Hagmann P, Graz MB, et al. Procedural pain and oral glucose in preterm neonates: brain development and sex-specific effects. Pain. 2018;159:515–25.
Stevens B, Yamada J, Lee GY, Ohlsson A Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database of Syst Rev. 2014:CD 001069.
Hall RW, Anand KJ. Pain management in newborns. Clin Perinatol. 2014;41:895–924.
Johnston C, Stevens B, Pinelli J, Gibbins S, Filion F, Jack A, et al. Kangaroo care is effective in diminishing pain response in preterm newborns. Arch Pediatr Adolesc Med. 2003;157:1084–8.
Johnston C, Campbell-Yeo M, Disher T, Benoit B, Fernandes A, Streiner D, et al. Skin-to-skin care for procedural pain in neonates (Review). Cochrane Database Syst Rev. 2017;2:CD008435.
Massaro AN, Hammad TA, Jazzo B, Aly H. Massage with kinesthetic stimulation improves weight gain in preterm infants. J Perinatol. 2009;19:352–7.
Field T, Diego M, Harnandez-Reif M, Dieter JN, Kumar AM, Schanberg S, et al. Insulin and insulin-like growth factor-1 increased in preterm infants following massage therapy. J Dev Behav Pediatr. 2008;29:463–6.
Guzzetta A, Baldini S, Bancale A, Baroncelli L, Ciucci F, Ghirri P, et al. Massage accelerates brain development and maturation of visual function. J Neurosci. 2009;29:6042–51.
Jain S, Kumar P, McMillan DD. Prior leg massage decreases pain responses to heel stick in preterm babies. J Paediatr Child Health. 2006;42:505–8.
Bellieni CV, Cordelli DM, Marchi S, Ceccarelli S, Perrone S, Maffei M, et al. Sensorial saturation for neonatal analgesia. Clin J Pain. 2007;23:219–21.
Chik YM, Ip WY, Chow KC. The effect of upper limb massage on infants venipuncture pain. Pain Manag Nurs. 2017;18:50–57.
Fitri SRY, Nasution AK, Nurhidayah I, Maryam NNA. Massage theraphy as a non-pharmacological analgesia for procedural pain in neonates: A scoping review. Complement Ther Med. 2021;59:102735.
Lawrence J, Alcock D, McGrath P, Kay J, MacMurray SB, Dulberg C. The development of a tool to assess neonatal pain. Neonatal Netw. 1993;12:59–66.
Suhrabi Z, Taghinejad H, Valian K, Sayehmiri K, Taheri S. A comparative study on the efficacy of glucose and sucrose on the vaccination pain: A randomized controlled clinical trial. J Clin Diagn Res. 2014;8:PC01–3.
Harrison D, Larocque C, Bueno M, Stokes Y, Turner L, Hutton B, et al. Sweet solutions to reduce procedural pain in neonates: a meta-analyses. Pediatrics. 2017;139:e20160955.
Bueno M, Harrison D, Khan S, Ohlsson A, Adams-Webber T, Beyene J, et al. A systematic review and meta- analyses of nonsucrose sweet solutions for pain relief in neonates. Pain Res Manag. 2013;18:153–61.
Deshmukh LS, Udani RH. Analgesic effect of oral glucose in preterm infants during venipuncture-A double- blind, randomized, controlled trial. J Trop Pediatr. 2002;48:138–41.
Bellieni CV, Bagnoli F, Cordelli DM, Perrone S, Nenci A, Buonocore G. Analgesia for premature children. Ital J Ped. 2003;29:286–90.
Jatana SK, Dalal SS, Wilson CG. Analgesic effect of oral glucose in neonates. MJAFI. 2003;59:100–4.
Matar EM, Arabiat DH, Foster MJ. Oral glucose efficacy on neonate’s pain responses at the NICU: A quasi experimental trial of two clinical procedures. Appl Nurs Res. 2016;32:36–40.
Hsieh KH, Chen SJ, Tsao PC, Wang CC, Huang CF, Lin CM, et al. The analgesic effect of non-pharmacological interventions to reduce procedural pain in preterm neonates. Pediatr Neonatol. 2018;59:71–76.
Chermont AG, Falcao LF, de Souza Silva EH, Balda RCX, Guinsburg R. Skin- to- skin contact and/or oral 25% dextrose for procedural pain relief for term newborn infants. Pediatrics. 2009;124:e1101–1107.
Pandita A, Panghal A, Gupta G, Verma A, Pillai A, Singh A, et al. Is kangaroo mother care effective in alleviating vaccination associated pain in early infantile period? A RCT. Early Hum Dev. 2018;127:69–73.
Castral TC, Warnock F, Leite AM, Haas VJ, Scochi CG. The effects of skin to skin contact during acute pain in preterm newborns. Eur J Pain. 2008;12:464–71.
Grunau RVE, Craig KD. Pain expression in neonates: facial action and cry. Pain. 1987;28:395–410.
The principal investigator HYY declare on behalf of all authors that authors have no financial interest.
The authors declare no competing interests.
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Yildizdas, H.Y., Erdem, B., Karahan, D.Y. et al. Effect of whole body massage on pain scores of neonates during venous puncture and comparison with oral dextrose and Kangaroo care, a randomized controlled evaluator-blind clinical study. J Perinatol (2022). https://doi.org/10.1038/s41372-022-01570-8