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Effect of whole body massage on pain scores of neonates during venous puncture and comparison with oral dextrose and Kangaroo care, a randomized controlled evaluator-blind clinical study



Newborns in NICUs experience many painful procedures. The aim of the study was to evaluate the effect of whole body massage therapy on pain scores during venipuncture and to compare with oral 10% dextrose and Kangaroo care.

Study design

Newborns with gestational age ≥34 weeks were randomly enrolled to one of three groups: dextrose, massage and Kangaroo care and a blinded investigator scored the pain using NIPS before and during the procedure.


There were 25, 26 and 23 newborns in dextrose, massage and Kangaroo care groups, respectively. Pain scores were similar before and during venipuncture in groups (p > 0.05). 36.5% of newborns (27/74) had severe pain scores. Number of newborns with no pain (score 0–2), moderate pain (score 3–4) and severe pain (score 5–7) were similar in each group.


Massage, Kangaroo and oral 10% dextrose had similar effects on pain scores during venipuncture.

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Fig. 1

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. All data generated or analyzed during this study are included in this published article.


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The principal investigator HYY declare on behalf of all authors that authors have no financial interest.

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Authors and Affiliations



HYY; Conception, design, supervision, writing, literature review. YS; Analysis and Interpretation. BE, DYK and OF; Supervision, materials, data collection.

Corresponding author

Correspondence to Ferda Ozlu.

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The authors declare no competing interests.

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Written informed consent was obtained from the parents of newborns included in the study.

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Yildizdas, H.Y., Erdem, B., Karahan, D.Y. et al. Effect of whole body massage on pain scores of neonates during venous puncture and comparison with oral dextrose and Kangaroo care, a randomized controlled evaluator-blind clinical study. J Perinatol (2022).

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