Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Journal Club
  • Published:

Which postnatal corticosteroid regimen is best for prevention of bronchopulmonary dysplasia?

Journal of Perinatology volume 42, pages 1699–1702 (2022)Cite this article

Subjects

Ramaswamy VV, Bandyopadhyay T, Nanda D, Bandiya P, Ahmed J, Garg A, Roehr CC, Nangia S. Assessment of Postnatal Corticosteroids for the Prevention of Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Network Meta-analysis. JAMA Pediatrics. 2021 Jun 1;175(6): e206826. https://doi.org/10.1001/jamapediatrics.2020.6826. Epub 2021 Jun 7. PMID: 33720274; PMCID: PMC7961472.

In infants born at 32 weeks gestational age or younger, which is the most appropriate postnatal corticosteroid regimen for the prevention of the composite outcome of death or bronchopulmonary dysplasia (BPD) at 36 weeks’ postmenstrual age (PMA)?

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Data availability

The datasets generated during and/or analyzed during the current study are available in the PubMed repository, https://doi.org/10.1001/jamapediatrics.2020.6826. https://pubmed.ncbi.nlm.nih.gov/33720274/. All other data are included in the paper.

References

  1. Ramaswamy VV, Bandyopadhyay T, Nanda D, Bandiya P, Ahmed J, Garg A, et al. Assessment of postnatal corticosteroids for the prevention of bronchopulmonary dysplasia in preterm neonates: a systematic review and network meta-analysis. JAMA Pediatrics. 2021;175:e206826 https://doi.org/10.1001/jamapediatrics.2020.6826

    Article  PubMed  PubMed Central  Google Scholar 

  2. Higgins RD, Jobe AH, Koso-Thomas M, Bancalari E, Viscardi R, Hartert T, et al. Bronchopulmonary dysplasia: executive summary of a workshop. J Pediatrics. 2018;197:300–8. https://doi.org/10.1016/j.jpeds.2018.01.043

    Article  Google Scholar 

  3. Watterberg KL, American Academy of Pediatrics, Committee on Fetus and Newborn. Policy statement—postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia. Pediatrics. 2010;126:800–8. https://doi.org/10.1542/peds.2010-1534

    Article  PubMed  Google Scholar 

  4. Cummings JJ, Pramanik AK. AAP Committee on Fetus and Newborn. Postnatal Corticosteroids to Prevent or Treat Chronic Lung Disease Following Preterm Birth. Pediatrics. 2022;149:e2022057530.

    Article  Google Scholar 

  5. Zeng L, Tian J, Song F, Li W, Jiang L, Gui G, et al. Corticosteroids for the prevention of bronchopulmonary dysplasia in preterm infants: a network meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2018;103:F506–F511. https://doi.org/10.1136/archdischild-2017-313759

    Article  PubMed  Google Scholar 

  6. Doyle LW, Cheong JL, Ehrenkranz RA, Halliday HL. Early (< 8 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants. Cochrane Database Syst Rev. 2017;10:CD001146 https://doi.org/10.1002/14651858.CD001146.pub5

    Article  PubMed  Google Scholar 

  7. Lemyre B, Dunn M, Thebaud B. Postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia in preterm infants. Paediatr Child Health. 2020;25:322–31. https://doi.org/10.1093/pch/pxaa073

    Article  PubMed  PubMed Central  Google Scholar 

  8. Wu K, Jensen E, White A, Wang Y, Biko D, Nilan K, et al. Characterization of Disease Phenotype in Very Preterm Infants with Severe Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2020;201:1398–406.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Watterberg KL, Walsh MC, Li L, Chawla S, D’Angio CT, Goldberg RN, et al. Eunice Kennedy Shriver NICHD Neonatal Research Network. Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia. N Engl J Med. 2022;386:1121–31. https://doi.org/10.1056/NEJMoa2114897. PMID: 35320643; PMCID: PMC9107291

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Cipriani A, Higgins JP, Geddes JR, Salanti G. Conceptual and technical challenges in network meta-analysis. Ann Intern Med. 2013;159:130–7.

    Article  PubMed  Google Scholar 

  11. Mills EJ, Thorlund K, Ioannidis JP. Demystifying trial networks and network meta- analysis. BMJ. 2013;346:f2914.

    Article  PubMed  Google Scholar 

  12. Thorlund K, Mills EJ. Sample size and power considerations in network meta-analysis. Syst Rev. 2012;1:41.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Song F, Xiong T, Parekh-Bhurke S, Loke YK, Sutton AJ, Eastwood AJ, et al. Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological study. BMJ. 2011;343:d4909.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Jansen JP, Naci H. Is network meta-analysis as valid as standard pairwise meta-analysis? It all depends on the distribution of effect modifiers. BMC Med. 2013;11:159.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Higgins JP, Jackson D, Barrett JK, Lu G, Ades AE, White IR. Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies. Res Synth Methods. 2012;3:98–110.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Mbuagbaw L, Rochwerg B, Jaeschke R, Heels-Andsell D, Alhazzani W, Thabane L, et al. Approaches to interpreting and choosing the best treatments in network meta-analyses. Syst Rev. 2017;6:79 https://doi.org/10.1186/s13643-017-0473-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The Journal Club is a collaboration between the American Academy of Pediatrics—Section of Neonatal Perinatal Medicine and the International Society for Evidence-Based Neonatology (EBNEO.org).

Author information

Authors and Affiliations

  1. Division of Newborn Medicine, Department of Pediatrics, Texas Children’s Hospital, Baylor College of Medicine, 6621 Fannin St Suite W6104, Houston, TX, 77030, USA

    J. D. Hammond, Joseph L. Hagan & Mohan Pammi

Authors
  1. J. D. Hammond
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joseph L. Hagan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohan Pammi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

JDH, II: Performed literature search and critical appraisal and wrote the primary draft. MP: Advised on the content of the paper and revised the primary draft. JLH: Advised on the content of the paper and revised the primary draft. All authors agree on the final paper as submitted and agree to be accountable for all aspects of work.

Corresponding author

Correspondence to J. D. Hammond.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hammond, J.D., Hagan, J.L. & Pammi, M. Which postnatal corticosteroid regimen is best for prevention of bronchopulmonary dysplasia?. J Perinatol 42, 1699–1702 (2022). https://doi.org/10.1038/s41372-022-01507-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-022-01507-1

Search

Advanced search

Quick links