Intestinal failure in neonatal and pediatric populations can be debilitating for patients and difficult to manage for clinicians. Management strategies include referral to an intestinal rehabilitation center, small volume trophic feeds to stimulate the intestine with cautious advancement of enteral nutrition using a standardized and evidence-based feeding protocol, and supplemental parenteral nutrition to optimize an infant’s growth and nutrition. In this review, we discuss the causes of intestinal failure, parenteral nutrition strategies, enteral feeding initiation and advancement protocols, as well as the challenges in feeding an infant with intestinal failure.
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We would like to thank Dr. Murali Premkumar and Laura Gollins for their contributions to the NICU Intestinal Rehabilitation Guidelines at Texas Children’s Hospital, Baylor College of Medicine.
ABH and MG are supported by the National Institutes of Health (NIH) grant R01DK124614, and MG is also supported by NIH grants R01DK118568 and R01HD105301. None of the funding sources had any role in this manuscript.
The authors declare no competing interests.
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Hair, A.B., Good, M. Dilemmas in feeding infants with intestinal failure: a neonatologist’s perspective. J Perinatol 43, 114–119 (2023). https://doi.org/10.1038/s41372-022-01504-4