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Costs associated with acute kidney injury in critically Ill neonates with patent Ductus arteriosus: pediatric health information system (PHIS) analysis

A Correction to this article was published on 03 November 2022

This article has been updated

Abstract

Objective

Compare costs of hospitalization between critically-ill neonates with patent ductus arteriosus (PDA) who did and did not develop acute kidney injury (AKI).

Study design

Using the Children’s Hospital Association’s Pediatric Health Information System (PHIS) database, we ascertained the marginal estimated total cost of hospitalization between those who did and did not develop AKI.

Results

Query of 49 PHIS centers yielded 14,217 neonates with PDA, 1697 with AKI and 12,520 without AKI. Predictors of cost included AKI, birth weight, ethnicity, race, length of stay (LOS), and Feudtner Complex Chronic Conditions Classification System. LOS was the strongest predictor (AKI: median 71 days [IQR 28–130]; No AKI: 28 days [10–76]; p < 0.01). Neonates with AKI had $48,416 greater costs (95% CI: $43,804–53,227) after adjusting for these predictors (AKI: $190,063, 95% CI $183,735–196,610; No AKI: $141,647, 95% CI $139,931–143,383 l; p < 0.01).

Conclusion

AKI is independently associated with increased hospital costs in critically-ill neonates with PDA.

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Fig. 1: Flow diagram detailing the study population.

Data availability

Datasets to be provided should they be requested.

Change history

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Funding

This study was funded in part by NIH/NCATS Grant Number UL1TR001450.

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Authors and Affiliations

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Contributions

HJS contributed to the concept and design of this project, the acquisition and interpretation of data, and draft and revision of the manuscript. She grants final approval of the submitted version and agrees to be accountable for all aspects of the work. DLB contributed to the concept and design of this project, the analysis and interpretation of data, and draft and revision of the manuscript. He grants final approval of the submitted version and agrees to be accountable for all aspects of the work. CC contributed to the acquisition of data and revision of the manuscript. She grants final approval of the submitted version and agrees to be accountable for all aspects of the work. CLW contributed to the concept and design of this project and revision of the manuscript. She grants final approval of the submitted version and agrees to be accountable for all aspects of the work. DTS contributed to the concept and design of this project, the interpretation of data, and revision of the manuscript. He grants final approval of the submitted version and agrees to be accountable for all aspects of the work. KET contributed to the concept and design of this project and revision of the manuscript. She grants final approval of the submitted version and agrees to be accountable for all aspects of the work. AMA contributed to the concept and design of this project and revision of the manuscript. He grants final approval of the submitted version and agrees to be accountable for all aspects of the work

Corresponding author

Correspondence to Heidi J. Steflik.

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Steflik, H.J., Brinton, D.L., Corrigan, C. et al. Costs associated with acute kidney injury in critically Ill neonates with patent Ductus arteriosus: pediatric health information system (PHIS) analysis. J Perinatol (2022). https://doi.org/10.1038/s41372-022-01499-y

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