Abstract
Objective
To evaluate serum creatinine (SCr) patterns and the development of acute kidney injury (AKI), as potential biomarkers of necrotizing enterocolitis (NEC).
Study design
Retrospective chart review of preterm infants with and without NEC born 23–32 weeks gestation admitted to Nationwide Children’s Hospital NICU. Medical versus surgical NEC was determined by radiographic and clinical findings. Available inpatient SCr levels obtained on days 8 through 365 were included.
Result
In this cohort, 77 NEC and a randomly selected group of 82 non-NEC infants met inclusion criteria. Fifteen of the 70 (21.4%) with NEC met criteria for AKI versus 0 of 43 (0.0%) without NEC. One of the 13 with AKI had AKI within 7 days prior to NEC diagnosis (7.7%).
Conclusion
AKI is more prevalent in infants with NEC. The temporal association between AKI and NEC could not be evaluated due to inconsistent SCr surveillance and should be evaluated in future studies.
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Data availability
The data that support the findings of this study are available within the article and are also available from the corresponding author, RH, upon reasonable request.
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Acknowledgements
This research was supported by the Ohio Perinatal Research Network of Nationwide Children’s Hospital.
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RH conceptualized and designed the study, collected data, assisted with data analysis, drafted the initial manuscript, and reviewed and revised the manuscript. SC and KJ analyzed data, made figures and tables, and reviewed and revised the manuscript for important intellectual contents. EB, JS and JM reviewed and revised the manuscript for important intellectual contents. TM assisted with the study design and data analysis and critically reviewed and revised several drafts of the manuscript. All authors approve the final manuscript as submitted and agree to be accountable for all aspects of the study.
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RH, SC, KJ, EB, JS, and TM have no conflicts of interest to disclose. JM serves on the advisory committee and speaker bureau for Ultragenyx and provides consultancy for OPKO.
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Han, R., Bonachea, E.M., Jackson, K. et al. Describing patterns in serum creatinine in infants with and without necrotizing enterocolitis. J Perinatol 43, 86–90 (2023). https://doi.org/10.1038/s41372-022-01482-7
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DOI: https://doi.org/10.1038/s41372-022-01482-7