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Chronic lung disease-related mortality in the US from 1999–2017: trends and racial disparities

Journal of Perinatology volume 42, pages 1244–1245 (2022)Cite this article

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A Correction to this article was published on 20 September 2022

This article has been updated

Bronchopulmonary dysplasia (BPD) is a serious morbidity in preterm infants and is the most common cause of chronic lung disease (CLD) in infants [1, 2]. Over the past two decades, infant mortality rates (IMR) have declined and, in 2018, were the lowest in US history. However, mortality trends among infants with CLD are not well described. Further, despite known racial disparities in infant mortality, racial disparities in CLD-related IMR are unknown.

We analyzed multiple-cause and birth/ infant death linked datasets using CDC WONDER from 1999 through 2017 to obtain cause-specific IMR up to 1 year of age and determined if temporal changes in CLD-related IMR differed by race [3]. CLD was defined as “chronic respiratory disease originating in the perinatal period” (ICD −10 code, P27), and included infants with BPD, “other”, and “unspecified” lung disease. IMR per 100,000 live births and by birth certificate-based maternal race were evaluated using Joinpoint regression, with tests of Parallelism to evaluate differences in trends by race [4]. We used the best-fit model, allowing up to 3 Joinpoints and reported IMR trends using annual percent change (APC) with 95% confidence intervals (CI).

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Fig. 1: Trends in CLD-related infant mortality in the United States, 1999–2017.

Data availability

The data is publicly at wonder.cdc.gov. Joinpoint regressions and statistical analyses will be made available upon request.

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Authors and Affiliations

  1. Emory University/Children’s Healthcare of Atlanta, 2015 Uppergate Drive NE, Atlanta, GA, 30322, USA

    Shilpa Vyas-Read & Ravi M. Patel

  2. University of Pennsylvania/The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Erik A. Jensen & Nicolas Bamat

  3. Medical College of Wisconsin/Children’s Wisconsin, Milwaukee, WI, USA

    Joanne M. Lagatta

  4. Northwestern University/Ann & Robert H Lurie Children’s Hospital, Chicago, IL, USA

    Karna Murthy

Authors
  1. Shilpa Vyas-Read
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  2. Erik A. Jensen
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  3. Nicolas Bamat
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  4. Joanne M. Lagatta
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  5. Karna Murthy
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  6. Ravi M. Patel
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Contributions

Study Design–SVR, RMP; Data Analyses, Manuscript preparation and Editing–SVR, JL, KM, EJ, NB, RMP.

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Correspondence to Shilpa Vyas-Read.

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The original online version of this article was revised: Figure 1 and the corresponding legend have been corrected. Reference 11 has been inserted in the text.

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Vyas-Read, S., Jensen, E.A., Bamat, N. et al. Chronic lung disease-related mortality in the US from 1999–2017: trends and racial disparities. J Perinatol 42, 1244–1245 (2022). https://doi.org/10.1038/s41372-022-01468-5

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