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  • Brief Communication
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Hypereosinophilia in NICU patients with a neonatal lymphatic flow disorder

Journal of Perinatology volume 42, pages 1538–1539 (2022)Cite this article

Subjects

Hypereosinophilia is defined as an absolute eosinophil count >1500 cells per microliter (c/µL) [1]. The incidence of pediatric hypereosinophilia has been reported to be 3.5 per 100,000 persons per year [2]. While mild or transient eosinophilia may be clinically insignificant, moderate to severe or persistent eosinophilia must be evaluated as it can be associated with life-threatening diagnoses [3].

Neonatal lymphatic flow disorders (NLFD) are also rare, estimated at 0.6% among live births [4]. These disorders include diagnoses of neonatal chylothorax and central lymphatic flow disorder. Central lymphatic flow disorder, also known as congenital lymphatic dysplasia, is a generalized lymphatic abnormality characterized by the presence of abnormal lymphatic flow or leak into more than one compartment, which can include the pleural space, peritoneum, pericardium, or dermis [5].

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De-identified data will be made available upon request after institutional data-sharing agreements are in place.

References

  1. Valent P, Klion AD, Horny HP, Roufosse F, Gotlib J, Weller PF, et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol. 2012;130:607–12.

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  2. Burris D, Rosenberg CE, Schwartz JT, Zhang Y, Eby MD, Abonia JP, et al. Pediatric hypereosinophilia: characteristics, clinical manifestations, and diagnoses. J Allergy Clin Immunol Pract. 2019;7:2750–8.

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  4. Lymphaticnetwork.org. New York: Lymphatic Education and Research Network; 2021. https://lymphaticnetwork.org.

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Acknowledgements

This work was supported by the Divisions of Neonatology and Cardiology at the Children’s Hospital of Philadelphia.

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Morgan E. Hill, Rachel F. Ledyard, Paul Wildenhain, Dalal Taha & Heather H. Burris

  2. Division of Neonatology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Morgan E. Hill

  3. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Dalal Taha, Yoav Dori & Heather H. Burris

  4. Division of Cardiology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Yoav Dori

Authors
  1. Morgan E. Hill
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  2. Rachel F. Ledyard
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  3. Paul Wildenhain
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  4. Dalal Taha
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  5. Yoav Dori
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  6. Heather H. Burris
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Contributions

MH helped to design the study and wrote the paper. RL performed data analysis and edited the paper. PW served as an honest broker to obtain matched controls and edited the paper. DT and YD provided cases with the use of the lymphatic registry and edited the paper. HB designed the study, mentored MH, and edited the paper.

Corresponding author

Correspondence to Heather H. Burris.

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Competing interests

The authors declare no competing interests. We received an invitation to submit this work as a brief communication. Abstract presented as a poster at the Pediatric Academic Society Research Conference (May 2021).

Ethics approval

The institutional review board at the Children’s Hospital of Philadelphia determined the study as exempt from IRB oversight (IRB 19-016794). The study was performed in accordance with the Declaration of Helsinki.

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Hill, M.E., Ledyard, R.F., Wildenhain, P. et al. Hypereosinophilia in NICU patients with a neonatal lymphatic flow disorder. J Perinatol 42, 1538–1539 (2022). https://doi.org/10.1038/s41372-022-01460-z

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  • DOI: https://doi.org/10.1038/s41372-022-01460-z

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