Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Accuracy of fetal middle cerebral artery Doppler ultrasound for moderate to severe fetal anemia prior to 24 weeks gestation

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Data availability

All data is available upon request.


  1. Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr., et al. Noninvasive diagnosis by doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. N. Engl J Med. 2000;6:9–14.

    Article  Google Scholar 

  2. Gravenhorst JB, Kanhai HH, Meerman RH, Ruys JH, Eernisse JG, Stroes TJ, et al. Twenty-two years of intra-uterine intraperitoneal transfusions. Eur J Obstet Gynecol Reprod Biol. 1989;33:71–7.

    Article  Google Scholar 

  3. van Kamp IL, Klumper FJCM, Oepkes D, Meerman RH, Scherjon SA, Vandenbussche FPHA, et al. Complications of intrauterine intravascular transfusion for fetal anemia due to maternal red-cell alloimmunization. Am J Obstet Gynecol. 2005;192:171–7.

    Article  Google Scholar 

  4. Zwiers C, Lindenburg TM, Klumper FJ, de Haas M, Oepkes D, Van Kamp IL. Complications of intrauterine intravascular blood transfusion: lessons learned after 1678 procedures. Ultrasound Obstet Gynecol. 2017;50:180–6.

    CAS  Article  Google Scholar 

  5. Kumar M, Umrawal T, Singh A. Middle cerebral artery Doppler reference centile charts for the prediction of fetal anemia in a population from India. Int J Gynecol Obstet. 2017;139:307–11.

    CAS  Article  Google Scholar 

Download references


The authors thank Kevin McClelland for identification of the cohort, David Guise for establishing the electronic data capture tool, and Surya Sruthi Bhamidipalli for statistical analysis.

Author information

Authors and Affiliations



KM completed the IRB submission, assisted with the literature search, performed the data collection, and wrote and revised the manuscript. SG assisted with the data collection and revision of the manuscript. AlS assisted with the IRB submission and the literature search and drafted components of the initial manuscript. MT reviewed and revised the manuscript. AnS designed the study, played an important role in interpretation of the results, and reviewed and revised the manuscript.

Corresponding author

Correspondence to Katherine Miller.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Miller, K., Green, S., Schiefer, A. et al. Accuracy of fetal middle cerebral artery Doppler ultrasound for moderate to severe fetal anemia prior to 24 weeks gestation. J Perinatol (2022).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI:


Quick links