Abstract
Objective
To study patterns of use of Fresh Frozen Plasma (FFP) and Cryoprecipitate (CRYO) in a level 4 NICU and assess what proportions were not supported by literature.
Study Design
single centered retrospective observational. Charts of neonates admitted between 1/1/2010 to 12/31/2017 to CT Children’s level 4 NICU were reviewed. Transfusions were assigned as “supported” or “non-supported” based on available evidence. Groups were compared using T-tests and chi-squared analyses.
Results
of 4110 total admissions, 197 (4.8%) received a total of 461 transfusions (374 FFP, 87 CRYO). Only 59% of FFP and 60% CRYO were supported by literature. Within the “non-supported” group the largest category was neonates transfused prophylactically.
Conclusion
A large proportion of transfusions administered to neonates was not evidence-based, suggesting there are opportunities for improvement in use of these products.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Data availability
All data generated or analyzed during this study are included in this published article [and its supplementary information files].
References
Motta M, Del Vecchio A, Perrone B, Ghirardello S, Radicioni M. FFP in the NICU: A prospective observational, multicentered study. Arch Dis Child Fetal Neonatal Ed. 2014;99:F303–308.
Puetz J, Witmer C, Huang YS, Raffini L. Widespread use of FFP in US children’s hospitals despite limited evidence demonstrating a beneficial effect. J Pediatr. 2012;160:210–15. e1
Potterjoy BS, Josephson CD. Platelets, Frozen Plasma and cryoprecipitate: What is the Clinical Evidence for their use in the neonatal intensive care unit? Semin Perinatol. 2009;33:66–74.
Pal S, Curley A, Stanworth SJ. Interpretation of clotting tests in the neonate. Arch Dis Child Fetal Neonatal Ed. 2015;100:F270–F274.
Andrew M, Paes B, Milner R, Johnston M, Mitchell L, Tollefsen DM, et al. Development of the human coagulation system in the healthy premature infant. Blood. 1988;72:1651–7.
Christensen RD, Baer VL, Lambert DK, Henry E, Ilstrup SJ, Bennett ST. Reference intervals for common coagulation tests of preterm infants. (CME). Transfusion. 2014;54:627–32.
Duguid J, O’Shaughnessy DF, Atterbury C, Bolton Maggs P, Murphy M, Thomas D, et al. British Committee for Standards in Haematology, Blood Transfusion Task Force. Guidelines for the use of fresh frozen plasma, cryoprecipitate and cryosupernatant. Br Soc Haematol. 2004;126:11–28.
Gross SJ, Filston HC, Anderson JC. Controlled study of treatment of disseminated intravascular coagulation in the neonate. J Pediatr. 1982;100:445–8.
Houben NA, Heeger LE, Stanworth SJ, New HV, Van der Bom JG, Fustolo-Gunnink S, et al. Changes in the use of FFP transfusions in preterm neonates: A single center experience. J Clin Med 2020;9:1–9.
GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group 2007 1(modified by the EBM Guidelines Editorial Team).
Altuntas N, Yenicesu I, Beken S, Kulali F, Burcu Belen F, Hirfanoglu IM, et al. Clinical use of fresh frozen plasma in neonatal intensive care units. Transfus Apher Sci. 2012;47:91–4.
Puetz J, Darling G, McCormick KA, Wofford JD. Fresh frozen plasma and recombinant factor VII a use in neonates. J Pediatr Hematol Oncol. 2009;31:901–6.
Baer VL, Lambert DK, Schmutz N, Henry E, Stoddard RA, Miner C, et al. Adherence to NICU transfusion guidelines: Data from a multihospital healthcare system. J Perinatol. 2008;28:492–7.
Erber WN, Perry DJ. Plasma and plasma products in the treatment of massive hemorrhage. Best Pr Res Clin Haematol. 2006;19:97–112.
Osborn DA, Evans N. Early volume expansion for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2004;2:CD002055.
Northern Neonatal Nursing Initiative (NNNI) Trial Group. A randomized trial comparing the effect of prophylactic intravenous FFP, gelatin or glucose on early mortality and morbidity in preterm babies. Eur J Pediatr. 1996;155:580–8.
Tripody A, Ramenghi LA, Chantarangkul V, De Carli A, Clerici M, Groppo M, et al. Normal thrombin generation in neonates in spite of prolonged conventional coagulation tests. Haematologica. 2008;93:1256–9.
Saxonhouse MA, Manco-Johnson MJ. The evaluation and management of neonatal coagulation disorders. Semin Perinatol. 2009;33:52–65.
Raffaeli G, Pesenti N, Cavallaro G, Cortesi V, Manzoni F, Amelio GS, et al. Optimizing fresh-frozen plasma transfusion in surgical neonates through thromboelastography: a quality improvement study. Eur J Pediatr. 2022 Feb. https://doi.org/10.1007/s00431-022-04427-6.
Josephson C, Hillyer CD Transfusion of plasma derivatives: fresh frozen plasma, cryoprecipitate, albumin and immunoglobulins, in Benz E, Cohen HJ, Furie B, et al. (eds.) Hematology, Basic Principles and Practice. (Ed 4) New York, NY, Churchill-Livingston, 2009.
Hensch LA, Indrikovs AJ, Shattuck KE Transfusion in ELBW premature neonates: Current practice trends, risks and early intervention to decrease need for transfusion, Neoreviews 2015;16: e287–e295.
Whyte RK, Kirpalani H, Asztalos E, Andersen C, Blajchman M, Heddle N, et al. Neurodevelopmental outcomes of ELBW infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusions, Pediatrics 2009;123:207–13.
Estcourt L, Standworth S, Murphy M. Prophylactic platelet transfusions. Curr Opin Hematol. 2010;17:411–7.
Christensen RD. Platelet transfusion in the neonatal intensive care unit: Benefits, risks, alternatives. Neonatology. 2011;100:311–8.
Stanworth SJ, Grant-Casey J, Lowe D, Laffan M, New H, Murphy MF, et al. The use of fresh frozen plasma in England: high levels of inappropriate use in adults and children. Transfusion. 2011;51:62–70.
Acknowledgements
Ahana Nagarkatti for technical support.
Author information
Authors and Affiliations
Contributions
SS was responsible for designing the study, extracting and analyzing data, interpreting the results, and writing the manuscript. MB was responsible for performing the statistical analysis. VH was responsible for designing the study, analyzing the data, and feedback and advising regarding the final manuscript.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sarkar, S., Brimacombe, M. & Herson, V. Fresh frozen plasma and cryoprecipitate: Can we safely reduce their use in the NICU?. J Perinatol 43, 226–230 (2023). https://doi.org/10.1038/s41372-022-01438-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41372-022-01438-x